Contents
Are You at Risk for Severe MS? Key Factors That Influence Disease Progression
Published: Aug 28, 2024
Not all cases of multiple sclerosis (MS) progress the same way. But what factors might indicate a higher risk of severe disease? Let's explore the key predictors of MS progression.
Demographic Factors
Several demographic factors can influence MS severity. These include being diagnosed after age 30, being male, and being of Black, Asian, or Hispanic ethnicity. Lifestyle factors also play a role - smoking, obesity, and a sedentary lifestyle are all associated with worse MS outcomes. Interestingly, while older age at onset is a risk factor, the frequency of relapses actually tends to decrease with age.
Clinical Factors
Certain clinical features can suggest a higher risk of severe MS. These include frequent relapses early in the disease course, poor recovery from relapses, and initial symptoms affecting motor function or balance (cerebellar symptoms). The presence of oligoclonal bands in the cerebrospinal fluid is another indicator of potentially more aggressive disease.
MRI Findings
MRI scans can provide valuable information about MS severity and prognosis. A high number of lesions, especially in the spinal cord, suggests more aggressive disease. The presence of 'black holes' (areas of severe tissue damage) and brain atrophy are also associated with worse outcomes. Ongoing disease activity, as shown by new or enlarging lesions on follow-up MRIs, is another red flag.
Frequently Asked Questions
It can increase risk, but doesn't necessarily predict severity.
Yes, early aggressive treatment often leads to better long-term outcomes.
No, some factors like early relapse frequency carry more weight.
Knowledge is Power
Understanding your risk factors can help guide treatment decisions and motivate lifestyle changes to manage MS more effectively.
References
- Dobson R, Giovannoni G. Multiple sclerosis - a review. Eur J Neurol 2019; 26:27.
- McKay KA, et al. Factors associated with onset, relapses or progression in multiple sclerosis: A systematic review. Neurotoxicology 2017; 61:189.
- Tintore M, et al. Defining high, medium and low impact prognostic factors for developing multiple sclerosis. Brain 2015; 138:1863.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
AI Doctor Visit Required
Appointments available 24/7
Top licensed doctors
Available in all 50 states
Full service care
Prescriptions, referrals & treatment
No insurance needed
All notes available in Doctronic
15-min consultation. No hidden costs.
AI Doctor Visit Required
Please Chat With Our AI Doctor First
Our AI doctor assessment helps our human doctors prepare for your video visit and provide better care
For safety reasons we have been forced to end this consultation.
If you believe this is a medical emergency please call 911 or your local emergency services immediately.
If you are experiencing emotional distress, please call the the Suicide & Crisis Lifeline at 988 or your local crisis services immediately.
Contact us
You can also email us at help@doctronic.ai
We aim to reply within 5-7 days
How likely are you to recommend Doctronic to friends or family?