Contents
Are You at Risk for HIT?
Published: Sep 11, 2023
Heparin-induced thrombocytopenia (HIT) can strike unexpectedly, but some people are at higher risk than others. This article explores the risk factors associated with HIT.
Surgical Patients
Patients undergoing surgery, especially cardiac or orthopedic procedures, have a higher risk of developing HIT. The stress of surgery combined with heparin exposure increases the likelihood of platelet activation. Being aware of this risk can lead to closer monitoring and early intervention.
Gender Differences
Interestingly, women have been found to have a higher incidence of HIT compared to men. This difference is particularly noted in those receiving unfractionated heparin. Understanding these gender-related risks can help in tailoring preventive measures and treatment plans.
Unfractionated Heparin Use
Unfractionated heparin, as opposed to its low molecular weight counterpart, is more likely to cause HIT. The larger complexes it forms with PF4 increase the immune response. Therefore, choosing alternatives when possible can mitigate this risk.
Frequently Asked Questions
Surgical patients and women receiving unfractionated heparin are at higher risk.
Women tend to have a higher incidence of HIT, especially with unfractionated heparin.
Yes, unfractionated heparin is more likely to cause HIT than low molecular weight heparin.
Understanding Risk
Knowing your risk factors for HIT can help you and your healthcare provider make informed decisions.
References
- Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995; 332:1330.
- Warkentin TE, Sheppard JA, Sigouin CS, et al. Gender imbalance and risk factor interactions in heparin-induced thrombocytopenia. Blood 2006; 108:2937.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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