When to Take Plan B: A Complete Guide to Emergency Contraception

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on January 23rd, 2026.

Key Takeaways

  • Plan B is most effective when taken within 24 hours of unprotected intercourse

  • Effectiveness decreases over time, dropping to 58% by 72 hours

  • Safe for most women, with few significant side effects

  • Consider consulting a healthcare provider for personalized advice

Emergency contraception provides a critical backup option for preventing unintended pregnancy. Plan B One-Step offers a reliable method for women seeking to reduce pregnancy risk after unprotected sexual activity or contraceptive failure. Understanding the nuanced details of when and how to use this medication can make a significant difference in its effectiveness.

Situations Requiring Emergency Contraception

Several key scenarios might necessitate the use of Plan B. Unprotected sexual intercourse represents the most common situation, which can occur due to spontaneous intimacy or unexpected circumstances. Birth control interactions can also create scenarios where emergency contraception becomes necessary, such as when medications interfere with regular birth control effectiveness.

Contraceptive failures provide another critical reason for considering emergency contraception. This includes situations like:

  • Condom breakage or slippage

  • Missed birth control pills

  • Medication interactions reducing contraceptive protection

  • Sexual assault survivors seeking preventive care

The Critical Timing Factor

Timing represents the most crucial element in Plan B's effectiveness. The medication works most optimally when taken quickly after unprotected intercourse:

Timing

Effectiveness Rate

Within 24 hours

95%

24-48 hours

85%

48-72 hours

58%

Some research suggests limited protection may exist up to 120 hours after intercourse, though effectiveness significantly diminishes. Women should prioritize taking Plan B as soon as possible to maximize pregnancy prevention.

Health and Safety Considerations

Before taking Plan B, women should evaluate several important health factors. Side effects of birth control can vary, and emergency contraception is no different. Body weight may impact effectiveness, with reduced efficacy potentially occurring in women weighing over 165 pounds.

Key considerations include:

  • Current pregnancy status

  • Liver health

  • Medication interactions

  • Breastfeeding status

What to Expect After Taking Plan B

Most women experience minimal side effects from Plan B. Temporary changes might include:

  • Slight menstrual cycle disruption

  • Mild cramping

  • Potential nausea

  • Slight breast tenderness

The Bottom Line

Emergency contraception provides an important option for preventing unintended pregnancy. While effective, it should not replace regular birth control methods. Need personalized guidance? Ready to meet your AI doctor? Get started with Doctronic today.

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