How Does Plan B Work? A Comprehensive Guide to Emergency Contraception

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on February 16th, 2026.

Key Takeaways

  • Plan B prevents pregnancy by delaying ovulation

  • Effectiveness ranges from 75-89% when taken within 3 days

  • Available over the counter for all ages and genders

  • Safe with minimal side effects

Emergency contraception is a critical healthcare option for individuals seeking to prevent unintended pregnancy. The Plan B morning-after pill provides a time-sensitive solution for those who have experienced unprotected sexual intercourse or contraceptive failure.

Plan B works primarily by preventing ovulation, which means it stops the release of an egg from the ovary. When taken quickly after unprotected sex, the medication can significantly reduce the chance of pregnancy. Interestingly, the medication is most effective when used within the first 72 hours, with effectiveness gradually decreasing over time.

Understanding Medication Mechanism

The active ingredient in Plan B, levonorgestrel, is a synthetic hormone that mimics progesterone. When you refill a prescription or seek emergency contraception, understanding how the medication works can help reduce anxiety.

Levonorgestrel works by temporarily stopping the release of an egg from the ovary. If no egg is released, fertilization cannot occur. The medication may also slightly change the uterine lining, making it less hospitable for potential fertilization.

Effectiveness and Timing

Plan B is most effective when taken as soon as possible after unprotected intercourse. The medication can be used up to five days after sexual contact, but effectiveness decreases with time. Within the first 24 hours, the prevention rate is highest at approximately 89%.

Individuals who are taking adapalene or other medications should consult a healthcare provider about potential interactions with emergency contraception.

Potential Side Effects

Most individuals experience minimal side effects from Plan B. Common temporary reactions include:

  • Slight changes in menstrual cycle

  • Mild headache

  • Potential nausea

  • Temporary breast tenderness

  • Abdominal pain

Cost and Accessibility

Brand

Average Cost

Availability

Plan B One-Step

$40-$50

Over the Counter

Generic Alternatives

$11-$45

Over the Counter

AfterPill (Online)

$25

Online Purchase

Medication Interactions

Some medications can reduce Plan B's effectiveness. When you're taking bactrim or other specific medications, consult a healthcare professional about potential interactions.

Medications that might decrease effectiveness include:

  • Rifampin

  • Certain HIV medications

  • Some anti-seizure drugs

  • St. John's Wort

Frequently Asked Questions

No, Plan B prevents pregnancy and does not terminate an existing pregnancy.

Yes, Plan B is available to all genders without age restrictions.

The medication begins working immediately after consumption to prevent ovulation.

Plan B may be less effective for individuals weighing over 165 pounds.

While safe, it's not recommended as a regular contraception method.

The Bottom Line

Emergency contraception provides an important healthcare option for preventing unintended pregnancy. Care you can trust. Doctronic is clinically validated with 99% treatment plan alignment.

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