Cortisone Shot for Acne: Everything You Need to Know

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on February 2nd, 2026.

Key Takeaways

  • Cortisone shots can rapidly reduce severe, painful acne cysts

  • Treatments take only minutes and can shrink inflammation within 24-48 hours

  • Best for deep, painful cystic acne that doesn't respond to topical treatments

  • Potential side effects include skin discoloration and potential indentation

Dealing with stubborn, painful acne can feel like an endless battle. While over-the-counter treatments might work for mild breakouts, some acne requires more targeted intervention. Enter the cortisone shot: a rapid, precise treatment for those massive, underground pimples that seem to have a mind of their own.

Cortisone shots are like a strategic surgical strike against severe acne. Unlike topical creams that slowly chip away at inflammation, these targeted injections can dramatically reduce swelling and pain in just hours. For anyone who has ever felt self-conscious or uncomfortable because of a massive, painful cyst, this treatment offers hope.

Understanding Cortisone Shots for Acne

Cortisone shots are a specialized medical procedure where a diluted corticosteroid is injected directly into an acne nodule or cyst. The goal is simple: reduce inflammation, minimize pain, and accelerate healing. These aren't your everyday pimple treatments. They're reserved for serious, deep-seated acne that laughs in the face of traditional skincare routines.

When to Consider a Cortisone Shot

Not every pimple is a candidate for a cortisone injection. These treatments are specifically designed for:

The Cortisone Shot Procedure

During the procedure, a dermatologist will:

  • Assess the specific acne lesion

  • Use a tiny 30-gauge needle for minimal discomfort

  • Inject a diluted corticosteroid directly into the cyst

  • Potentially mix in a local anesthetic for pain management

Procedure Detail

Description

Duration

2-5 minutes

Needle Size

30-gauge (very small)

Pain Level

Minimal

Recovery Time

Immediate

Potential Side Effects and Considerations

While cortisone shots can be miraculous, they're not without risks. Potential side effects include:

  • Temporary skin lightening

  • Small indentation at injection site

  • Rare instances of skin atrophy

  • Potential bruising

Patients with recurring acne might want to explore broader treatment strategies beyond individual cortisone shots.

Aftercare and Expectations

Most patients experience rapid improvement:

  • Inflammation reduces within hours

  • Cyst size dramatically decreases in 24-48 hours

  • Minimal recovery time required

  • Potential for immediate return to normal activities

Frequently Asked Questions

Most patients report minimal discomfort, often describing it as a quick pinch.

Dermatologists typically recommend limiting treatments to prevent potential skin damage.

Coverage varies. Consult your specific insurance provider.

Not all patients are ideal candidates. A dermatologist will assess individual skin conditions.

No, they treat existing cysts but don't prevent new acne formation.

The Bottom Line

Cortisone shots offer a targeted solution for severe, persistent acne. While effective, they're not a long-term treatment strategy. Ready to explore personalized acne solutions? Care you can trust. Doctronic is clinically validated with 99% treatment plan alignment.

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