Cortisone Shot for Acne: What You Need to Know Before Getting Treated

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on January 31st, 2026.

Key Takeaways

  • Cortisone shots can rapidly reduce severe, painful acne cysts

  • Treatment takes just minutes and can dramatically reduce inflammation

  • Not recommended for all types of acne breakouts

  • Potential side effects include skin discoloration and potential scarring

Dealing with severe acne can be frustrating and emotionally challenging. When over-the-counter treatments fail, many people turn to more advanced solutions like cortisone shots. These targeted injections offer a quick way to address painful, deep acne cysts that resist traditional treatments.

Cortisone shots are a specialized medical intervention designed to tackle the most stubborn and inflammatory acne lesions. Unlike typical topical treatments, these injections work directly at the source of inflammation, providing rapid relief and healing.

Understanding Cortisone Shots for Acne

Cortisone shots involve injecting a diluted corticosteroid directly into an acne nodule or cyst. The primary goal is to reduce inflammation, minimize pain, and accelerate healing. Dermatologists typically recommend these acne treatments for specific types of severe breakouts.

When Are Cortisone Shots Appropriate?

Not all acne is suitable for cortisone injections. These shots work best for:

  • Deep, painful cystic acne

  • Large, inflamed blemishes

  • Acne that hasn't responded to topical treatments

  • Lesions at risk of causing significant scarring

Timing and Selection

Dermatologists carefully evaluate which blemishes are appropriate for cortisone shots. Ideal candidates are large, persistent acne lesions that are red, swollen, and particularly painful.

The Treatment Procedure

Procedure Step

Details

Preparation

No special skin preparation required

Injection

Small 30-gauge needle used

Duration

Typically 30 seconds to a few minutes

Anesthesia

Optional local anesthetic available

During the procedure, patients are usually positioned comfortably and asked to remain still. The tiny needle minimizes discomfort, and some doctors can mix a local anesthetic with the cortisone for additional pain reduction.

Potential Risks and Side Effects

While cortisone shots can be effective, they aren't without risks. Potential side effects include:

  • Temporary skin discoloration

  • Minor skin depression or scarring

  • Potential lightening of the treated area

  • Rare instances of infection

Patients should understand acne scar prevention and discuss potential long-term implications with their healthcare provider.

Frequency and Considerations

Experts recommend limiting cortisone shots. They are not a long-term solution but rather an emergency intervention for particularly challenging acne lesions. Overuse can potentially lead to skin damage or uneven texture.

Frequently Asked Questions

Most patients report minimal discomfort due to the small needle size and optional local anesthetic.

Many patients see significant improvement within 24-48 hours after the injection.

Not everyone is a suitable candidate. Consultation with a dermatologist is essential.

Yes, including topical treatments, oral medications, and comprehensive skincare routines.

Prices vary but typically range from $100-$300 per injection, depending on location and provider.

The Bottom Line

Cortisone shots can be an effective solution for stubborn, painful acne cysts. However, they should be used judiciously and as part of a comprehensive skincare strategy.

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