Cortisone Injection for Acne: A Targeted Treatment for Stubborn Breakouts

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on January 30th, 2026.

Key Takeaways

  • Cortisone injections rapidly reduce inflammation in severe acne cysts

  • Treatment provides quick relief within 24-48 hours

  • Most effective for large, painful acne lesions measuring 5mm or more

  • Potential to prevent scarring and reduce treatment time

Dealing with severe, stubborn acne can be frustrating and emotionally challenging. When traditional treatments fail, cortisone injections for acne emerge as a powerful solution for those persistent, painful breakouts. These targeted treatments offer hope for individuals struggling with deep, inflammatory acne that resists topical medications.

Cortisone injections represent a precise medical intervention designed to address the most challenging acne lesions. Unlike over-the-counter treatments, this procedure involves directly injecting a diluted corticosteroid medication into individual acne cysts or nodules. The goal is to quickly reduce inflammation, minimize pain, and prevent potential scarring.

Understanding Cortisone Injections

Dermatologists use cortisone injections as a specialized treatment for severe acne. The procedure involves injecting a diluted corticosteroid, typically triamcinolone acetonide, directly into inflamed acne lesions. This targeted approach allows for rapid reduction of swelling, redness, and discomfort associated with deep, painful acne cysts.

Mechanism of Action

The injection works by directly suppressing the inflammatory response within the acne lesion. When cortisone is introduced, it quickly reduces swelling and breaks down the thick, fibrous walls of cystic lesions. Treating acne naturally can be challenging, which is why this medical intervention proves so effective for severe cases.

Treatment Candidacy

Not all acne responds to cortisone injections. Ideal candidates typically have:

  • Large, deep inflammatory cysts

  • Lesions measuring at least 5 millimeters

  • Acne that has not responded to topical treatments

  • Risk of significant scarring

Procedure and Expectations

The injection process is relatively quick and straightforward. A dermatologist will:

  1. Clean the treatment area

  2. Use a fine needle to inject diluted cortisone

  3. Target the center of the inflammatory lesion

  4. Complete the procedure in seconds

Most patients experience significant improvement within 24 to 48 hours. Acne scars can be prevented by addressing inflammatory lesions quickly and effectively.

Potential Side Effects and Considerations

Side Effect

Likelihood

Duration

Management

Skin Atrophy

Low

Temporary

Resolves naturally

Skin Discoloration

Moderate

Temporary

Monitoring

Minor Indentation

Possible

3-6 months

Professional assessment

Patients should be aware of potential temporary side effects, including minor skin depression or temporary lightening at the injection site. These effects are typically short-lived and resolve without intervention.

Cost and Insurance

Cortisone injection costs range from $25 to $100 per treatment. Many insurance plans cover the procedure when deemed medically necessary. Treating persistent acne can be expensive, so checking insurance coverage is recommended.

Frequently Asked Questions

Most patients report minimal discomfort, with a quick pinching sensation during the injection.

Dermatologists typically limit treatments to prevent potential skin complications.

The treatment addresses specific lesions but does not prevent future acne breakouts.

Not all patients are ideal candidates. Consultation with a dermatologist is crucial.

Most patients notice significant improvement within 24-48 hours.

The Bottom Line

Cortisone injections offer a powerful solution for stubborn, inflammatory acne that resists traditional treatments. Ready to meet your AI doctor? Get started with Doctronic today.

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