9 Common and Serious Side Effects of Levofloxacin

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 3rd, 2025.

Key Takeaways

  • Levofloxacin is a widely used antibiotic, but it can cause side effects ranging from mild to serious.

  • Common side effects include nausea, headache, and dizziness, while serious ones may involve tendon damage and nerve problems.

  • Knowing how to recognize and manage these side effects helps you stay safe while using this medication.

  • If you have questions or need personalized advice, services like Doctronic.ai offer fast, expert telehealth support.

Understanding Levofloxacin Side Effects

Levofloxacin is a fluoroquinolone antibiotic used to treat various bacterial infections, including pneumonia, urinary tract infections, and skin infections. Because of its strength, it should be used only as prescribed to help prevent antibiotic resistance. Patients should also watch for drug interactions - such as with magnesium - or aluminum-containing antacids - and keep their healthcare provider informed about all medications and supplements to ensure safe and effective treatment.

1. Nausea and Upset Stomach

Nausea is one of the most common side effects of Levofloxacin. It happens because the medicine can irritate your stomach lining. You might feel queasy or even vomit occasionally. This side effect usually starts soon after taking the medication and can last for a few days.

To reduce nausea, try taking Levofloxacin with food unless your doctor says otherwise. Drinking plenty of water can also help soothe your stomach. If nausea becomes severe or lasts longer than a week, contact your healthcare provider.

2. Headache

Many people report headaches while taking Levofloxacin. These headaches can range from mild to moderate and often improve as your body adjusts to the medication. Staying hydrated and resting in a quiet, dark room can ease the discomfort.

If headaches become intense or are accompanied by vision changes or confusion, seek medical attention immediately. These could be signs of more serious issues.

3. Dizziness and Lightheadedness

Dizziness is another side effect some experience with Levofloxacin. It may occur because the drug affects your nervous system or blood pressure. Feeling lightheaded can increase your risk of falls, so be cautious when standing up quickly or walking.

Avoid driving or operating heavy machinery if you feel dizzy. If dizziness persists or worsens, talk to your doctor about adjusting your treatment.

4. Tendon Pain and Risk of Tendon Rupture

Levofloxacin has been linked to tendon problems, including pain, inflammation, and in rare cases, tendon rupture. This side effect is more common in older adults and people who use steroids or have kidney, heart, or lung transplants.

If you notice pain, swelling, or difficulty moving a joint, especially in the Achilles tendon, stop taking Levofloxacin and contact your healthcare provider right away. Early treatment can prevent serious damage.

5. Nerve Damage (Peripheral Neuropathy)

Some patients experience peripheral neuropathy, a condition that causes nerve damage.
This can cause tingling, numbness, burning, or weakness in the hands or feet. These symptoms might appear during or after treatment and can sometimes be permanent.

Report any unusual sensations or muscle weakness to your doctor immediately to minimize the risk of lasting nerve injury.

6. Diarrhea and Digestive Issues

Diarrhea is a common side effect linked to many antibiotics, including Levofloxacin. It occurs because the medication can disrupt the natural balance of bacteria in your gut. Usually, mild diarrhea resolves on its own.

Drink plenty of fluids to avoid dehydration. If diarrhea is severe, bloody, or lasts more than a few days, seek medical care, as this could signal a serious infection called Clostridium difficile colitis.

7. Changes in Mood or Sleep

Levofloxacin may affect your brain and mood. Some people report feeling anxious, confused, or having trouble sleeping. These central nervous system effects can be distressing.

If you experience mood swings, hallucinations, or severe insomnia, contact your healthcare provider. They may recommend stopping the medication or trying alternatives.

8. Photosensitivity (Sun Sensitivity)

Levofloxacin can make your skin more sensitive to sunlight, increasing the risk of sunburn. This happens because the drug affects how your skin reacts to UV rays.

Wear sunscreen, protective clothing, and avoid prolonged sun exposure while taking this medication. If you develop a rash or severe sunburn, notify your doctor.

9. Changes in Heart Rhythm

In rare cases, Levofloxacin can affect your heart’s rhythm, causing a condition called QT prolongation. This can lead to irregular heartbeats, which might be dangerous if you have existing heart problems. In rare cases, aortic damage is a possibility.

Symptoms to watch for include palpitations, fainting, or dizziness. If you experience these, seek emergency medical help immediately.

A pile of white oval tablets scattered on a plain surfaceHow to Manage and Reduce Side Effects of Levofloxacin

Take Medication Exactly as Prescribed

Follow your doctor’s instructions carefully. Don’t skip doses or stop the medication early without consulting your healthcare provider. Proper use helps reduce side effects and improves treatment success.

Stay Hydrated and Eat Light Meals

Drinking water and eating small, bland meals can help prevent nausea and stomach upset. Avoid alcohol and caffeine, which may worsen side effects.

Protect Your Skin

Use sunscreen and cover up when outdoors to avoid photosensitivity reactions. This simple step can prevent painful sunburns.

Report Symptoms Early

Keep track of any new or worsening symptoms. Early communication with your healthcare provider can prevent complications and improve outcomes.

Levofloxacin Allergic Reactions and Warnings

While rare, allergic reactions to Levofloxacin can be serious. Signs include rash, itching, swelling of the face or throat, difficulty breathing, or severe dizziness. These symptoms require immediate medical attention.

People with a history of allergies to fluoroquinolone antibiotics should avoid Levofloxacin. Always inform your healthcare provider about any allergies before starting treatment.

When to Contact Your Doctor About Levofloxacin Side Effects

Contact your doctor if you experience:

  • Severe or persistent nausea, vomiting, or diarrhea

  • Sudden joint or tendon pain

  • Tingling, numbness, or weakness in your limbs

  • Mood changes or confusion

  • Signs of allergic reaction, like swelling or difficulty breathing

  • Irregular heartbeat or fainting

Prompt medical advice can prevent serious complications and help adjust your treatment safely.

Learn More About Levofloxacin Side Effects With Doctronic

Levofloxacin side effects can vary from person to person. For personalized information and advice, Doctronic.ai offers AI-powered doctor visits that provide fast, detailed answers based on the latest medical research. You can ask questions anytime and get tailored recommendations that fit your health history.

Doctronic.ai provides convenient telehealth video visits with licensed doctors across all 50 states. This means expert help is just a few clicks away, whether you need a second opinion or treatment guidance.

The Bottom Line About Levofloxacin Side Effects

Levofloxacin is a powerful antibiotic that can help fight infections effectively. Being aware of its common and serious side effects ensures you can use it safely. If you have any concerns or unusual symptoms, don’t hesitate to reach out to healthcare professionals.

Doctronic.ai makes it easy to get expert advice quickly from the comfort of your home. This can be especially helpful if you want to understand your side effects better or need guidance on managing them.

Frequently Asked Questions

Fatigue can occur, but it usually improves as your body adjusts. If tiredness is severe or lasts beyond treatment, talk to your doctor.

Some drugs can interact with Levofloxacin. Always tell your healthcare provider about all medications and supplements you take to avoid harmful interactions.

Most side effects fade within a few days after finishing the medication.
Some, like nerve damage or tendon issues, may last longer and need medical evaluation.

Levofloxacin is generally not recommended for children unless prescribed by a doctor for specific conditions. Pediatric use requires careful monitoring.

Take the missed dose as soon as you remember, unless it’s near the time for your next dose. Do not double up doses.

References

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