8 Common and Serious Side Effects of Nexplanon

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 19th, 2025.

Key Takeaways

  • Nexplanon is a popular long-acting contraceptive implant, but it can cause a range of side effects, both common and serious.

  • Common side effects include changes in menstrual bleeding, mood swings, headaches, and weight fluctuations.

  • Serious side effects, though rare, may involve blood clots, severe allergic reactions, and implant site complications.

  • Understanding how to manage side effects can improve comfort and safety while using Nexplanon.

  • Consulting with healthcare professionals through telehealth platforms like Doctronic.ai can provide personalized advice and care.

Understanding Nexplanon Side Effects

Nexplanon is a highly effective, long-acting contraceptive implant placed under the skin of the upper arm. It continuously releases a low dose of Etonogestrel, a progestin hormone that prevents ovulation and thickens cervical mucus to reduce the likelihood of pregnancy. Offering protection for up to three years, Nexplanon appeals to many users because it eliminates the need for daily pills or frequent clinic visits. Understanding potential side effects is essential for making an informed decision. One of the most common concerns is irregular bleeding, which may include lighter periods, prolonged spotting, or unpredictable cycles, especially during the first several months. Tracking these changes in a menstrual diary can help patients identify patterns and discuss concerns with their healthcare provider.

Beyond physical symptoms, Nexplanon may also influence mood and emotional well-being. Some users report experiencing anxiety, irritability, or depressive feelings as their body adjusts to hormonal changes. Open communication with a healthcare professional is key to addressing these issues, whether through lifestyle adjustments or exploring alternative contraceptive options. Doctronic.ai provides convenient access to personalized guidance, helping users navigate side effects, optimize their contraceptive experience, and feel confident in their reproductive health decisions.

1. Changes in Menstrual Bleeding

One of the most common side effects of Nexplanon involves changes to menstrual bleeding patterns. Many users experience irregular bleeding, spotting between periods, or prolonged bleeding. Some may have lighter periods, while others might stop menstruating altogether.

This happens because the hormone in Nexplanon affects the lining of the uterus, altering the normal cycle. For most, these changes stabilize after a few months, but if bleeding becomes heavy or persistent, it's important to consult a healthcare provider.

2. Headaches and Migraines

Headaches are frequently reported by Nexplanon users. Hormonal fluctuations can trigger tension headaches or migraines, especially in those with a history of migraines. While usually manageable with over-the-counter pain relief, severe or worsening headaches should be evaluated by a doctor.

3. Weight Changes

Some users notice weight gain or loss after getting Nexplanon. Hormones can influence appetite, fluid retention, and metabolism, leading to these fluctuations. Studies show weight changes vary greatly and aren't guaranteed for everyone.

Maintaining a balanced diet and regular exercise can help manage any unwanted weight changes.

4. Mood Swings and Emotional Changes

Hormonal contraceptives like Nexplanon can affect mood. Some users report mood swings, irritability, or feelings of depression. While these symptoms are often mild, they can impact quality of life.

If emotional changes become severe or persistent, seeking professional support is crucial. Mental health is as important as physical health, and help is available.

5. Acne and Skin Changes

Hormonal shifts from Nexplanon can cause skin changes such as acne flare-ups or, less commonly, improvement in skin condition. These effects depend on individual hormone sensitivity.

Skincare routines may need adjustment, and dermatological advice can be helpful if acne worsens significantly.

6. Breast Tenderness and Pain

Breast tenderness or mild pain is another common side effect. Hormones increase breast tissue sensitivity, which usually subsides after the body adjusts to the implant.

If breast pain is severe or accompanied by lumps, medical evaluation is advised to rule out other conditions.

7. Implant Site Reactions

Since Nexplanon is inserted under the skin, some users experience redness, swelling, or pain at the implant site. These reactions are typically mild and resolve within days or weeks.

Rarely, infections or implant migration can occur, which require prompt medical attention.

8. Serious Blood Clot Risks

Though rare, Nexplanon can increase the risk of blood clots, which may lead to deep vein thrombosis (DVT), pulmonary embolism, or stroke. Symptoms such as sudden leg pain, swelling, chest pain, or shortness of breath should prompt immediate medical care.

Women with a history of clotting disorders or certain risk factors should discuss alternatives with their healthcare provider.

Gloved hand holding a small contraceptive implant rod between two fingersHow to Manage and Reduce Side Effects of Nexplanon

Managing Menstrual Changes

Tracking bleeding patterns can help users understand their body's response. Over-the-counter pain relievers and sanitary products can ease discomfort. If bleeding is heavy or prolonged, a healthcare provider can offer treatments or consider alternative contraception.

Addressing Headaches

Regular hydration, stress management, and avoiding headache triggers like caffeine or certain foods may reduce headache frequency. If headaches persist, a doctor can recommend medications or evaluate other causes.

Handling Mood and Skin Changes

Open communication with healthcare professionals about mood shifts is important. Counseling or medication might be necessary in some cases. For acne, gentle skincare and dermatologist consultation can improve symptoms.

Reducing Implant Site Discomfort

Applying ice packs and keeping the area clean can ease pain and swelling. Any signs of infection require prompt medical evaluation.

Nexplanon Allergic Reactions and Warnings

Severe allergic reactions to Nexplanon are uncommon but possible. Signs include rash, itching, swelling, dizziness, or difficulty breathing. Immediate emergency care is necessary if these symptoms appear.

Before insertion, patients should inform their doctor of any allergies or sensitivities.

When to Contact Your Doctor About Nexplanon Side Effects

Immediate medical attention is required for symptoms such as severe chest pain, difficulty breathing, sudden leg swelling, or signs of allergic reaction. Persistent or worsening side effects such as heavy bleeding, severe headaches, or intense mood changes also warrant consultation.

For non-urgent concerns, telehealth services offer a convenient way to get professional advice. Doctronic.ai provides quick, affordable access to doctors who can personalize guidance based on your health history.

Learn More About Nexplanon Side Effects With Doctronic

Doctronic is an AI-powered healthcare platform that offers free AI doctor visits and affordable telehealth consultations with licensed physicians. It synthesizes the latest medical research to provide accurate, personalized answers about Nexplanon side effects and management strategies.

Whether you want a second opinion or need help understanding your symptoms, Doctronic remembers your medical history and offers care tailored to you. Visit Doctronic.ai to get started anytime, from anywhere in the U.S.

The Bottom Line About Nexplanon Side Effects

Nexplanon offers effective, long-term contraception with the convenience of a single implant. Like any medication or device, it comes with possible side effects that range from mild to serious. Being aware of these effects helps users manage their health proactively.

If side effects arise, timely communication with healthcare professionals is key. Doctronic makes expert advice accessible without the hassle of in-person visits. This approach supports safer, more comfortable contraceptive use and peace of mind.

Frequently Asked Questions

Some users report weight changes, but research shows this varies widely. Hormonal effects on appetite and metabolism differ by individual. Maintaining a healthy lifestyle helps manage any fluctuations.

Irregular bleeding or spotting is common, especially in the first few months. If bleeding is heavy or lasts more than a few weeks, consult your healthcare provider.

Many side effects improve within 3 to 6 months as the body adjusts. Persistent or severe symptoms should be evaluated by a doctor.

Yes, Nexplanon can be removed at any time by a healthcare professional. Fertility usually returns quickly after removal.

Telehealth services like Doctronic.ai offer personalized consultations with licensed doctors who can help you understand and manage side effects effectively.

References

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