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7 Common and Serious Side Effects of Stendra

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on November 30th, 2025.

Key Takeaways

  • Avanafil (Stendra) blocks PDE5 enzymes to increase blood flow, but can cause headaches in 10-15% of users and facial flushing that typically peaks within 30-60 minutes of taking the medication.

  • Serious cardiovascular events include dangerous blood pressure drops when combined with nitrates, chest pain, and irregular heartbeat—particularly risky for men with existing heart conditions.

  • Sudden vision loss (NAION) occurs in less than 1% of users but requires immediate emergency care, as does priapism (erections lasting over 4 hours) which can cause permanent damage.

  • Starting doses should not exceed 100mg, with many men finding 50mg effective; alcohol increases side effect severity and reduces the medication's effectiveness.

  • Back pain and muscle aches affect roughly 3-5% of users and usually resolve within 48 hours, while nasal congestion occurs due to blood vessel dilation in sinus tissues.

Understanding Stendra Side Effects

Stendra is a popular choice for men seeking help with erectile dysfunction. Like many medications, it can cause side effects that vary from person to person. Knowing what to expect can help you use Stendra safely and feel confident about your treatment. This article breaks down seven common and serious side effects of Stendra, how to manage them, and when to get help.

1. Headache

One of the most common side effects of Stendra is headache. This happens because the medication widens blood vessels, which can increase blood flow but also cause mild pressure changes in your head. Most headaches from Stendra are mild to moderate and usually go away within a few hours.

To reduce headaches, try taking Stendra with food or staying hydrated. Over-the-counter pain relievers like Acetaminophen can help, but avoid taking aspirin or ibuprofen without checking with a doctor first. If headaches persist or become severe, it’s a good idea to talk to a healthcare provider.

2. Flushing

Flushing means your face, neck, or chest might feel warm and look red. This happens because Stendra relaxes blood vessels, increasing blood flow near the skin’s surface. Flushing is usually mild and temporary, lasting less than an hour.

To manage flushing, avoid hot drinks, spicy foods, and alcohol around the time you take Stendra. These can make flushing worse. If flushing is uncomfortable or lasts a long time, reach out to a healthcare professional for advice.

3. Nasal Congestion

Stendra can cause nasal congestion or a stuffy nose. This happens because the medication affects blood vessels in the nasal passages, leading to swelling and blockage. It’s a mild side effect but can be annoying, especially if you already have allergies or a cold.

Using a saline nasal spray or a humidifier might ease congestion. Avoid overusing nasal decongestant sprays, as they can worsen symptoms if used too long. If nasal congestion becomes severe or persistent, consult your doctor.

4. Dizziness

Feeling dizzy or lightheaded is another side effect some people experience with Stendra. This is linked to the medication’s effect on blood pressure, which can drop suddenly when standing up. Dizziness can increase the risk of falls, so it’s important to be cautious.

To reduce dizziness, stand up slowly from sitting or lying down. Avoid alcohol and other medications that lower blood pressure while using Stendra. If dizziness is severe or causes fainting, seek medical help immediately.

5. Back Pain and Muscle Aches

Some users report back pain or muscle aches after taking Stendra. These symptoms usually start a few hours after taking the medication and can last up to two days. The exact cause isn’t fully understood, but it may relate to changes in blood flow or muscle relaxation.

Rest, gentle stretching, and over-the-counter pain relievers can help ease these aches. If pain is severe or lasts longer than a couple of days, a healthcare provider should evaluate it.

6. Vision Changes

Serious but rare, vision changes like blurred vision or a blue tint can occur with Stendra. This happens because the medication affects blood flow in the eyes. If you notice sudden vision loss, trouble seeing colors, or other changes, this is an emergency.

Stop taking Stendra immediately and get medical help right away. Early treatment can prevent permanent damage.

7. Chest Pain and Heart Issues

Chest pain, irregular heartbeat, or shortness of breath are serious side effects that require urgent care. Stendra affects blood vessels and blood pressure, which can strain the heart, especially in people with heart conditions.

If you experience chest pain or heart symptoms after taking Stendra, call emergency services or go to the nearest hospital. Do not take any more of the medication until a doctor says it’s safe.

A doctor handing a patient a blister pack of pills across a desk with medical forms and medication bottlesHow to Manage and Reduce Side Effects of Stendra

Start with a Low Dose

Starting with the lowest effective dose can help your body adjust and reduce side effects. Your doctor can guide you on the right dose based on your health and other medications.

Take Stendra as Directed

Follow the instructions carefully. Avoid taking Stendra with nitrates or certain other medications, as this can cause dangerous drops in blood pressure.

Stay Hydrated and Avoid Alcohol

Drinking water and limiting alcohol can reduce headaches, dizziness, and flushing. Alcohol can also interfere with how well Stendra works.

Use Over-the-Counter Remedies Wisely

Pain relievers and saline sprays can ease some side effects, but always check with a healthcare provider before combining treatments.

Stendra Allergic Reactions and Warnings

While rare, allergic reactions to Stendra can happen. Signs include rash, itching, swelling of the face or throat, severe dizziness, or trouble breathing. These require immediate emergency care.

People with heart problems, low blood pressure, or those taking nitrates should avoid Stendra. Always tell your doctor about your full medical history before starting this medication.

When to Contact Your Doctor About Stendra Side Effects

If you experience any of the following, contact a healthcare provider promptly:

  • Severe or persistent headaches

  • Sudden vision changes or loss

  • Chest pain or heart palpitations

  • Severe dizziness or fainting

  • Signs of an allergic reaction

For quick advice or to discuss your symptoms, consider using Doctronic.ai. This AI-powered doctor offers free AI visits and affordable telehealth video visits with real doctors 24/7 across the U.S. It’s a smart, fast way to get personalized medical guidance without leaving home.

Learn More About Stendra Side Effects With Doctronic

Doctronic is revolutionizing healthcare by combining AI with expert medical knowledge. It can provide detailed, personalized information about Stendra’s side effects based on your health history. Whether you want to understand common side effects or need help managing serious symptoms, Doctronic is a trusted resource.

Visit Doctronic.ai to try free AI doctor visits or schedule a telehealth appointment with a licensed physician. With over 10 million users, Doctronic is the #1 AI doctor delivering modern, personal care in seconds.

The Bottom Line About Stendra Side Effects

Stendra offers an effective way to manage erectile dysfunction, but like all medications, it comes with potential side effects. Most are mild and short-lived, but some require prompt medical attention. Knowing what to expect and how to handle side effects can make your treatment smoother and safer.

For personalized advice and easy access to care, Doctronic.ai is a great option. It combines AI with real doctors to give you fast, smart, and personal medical support anytime you need it.

Frequently Asked Questions

Most side effects of Stendra are short-term and go away after the medication wears off. Long-term side effects are rare but possible if the medication is misused or taken with contraindicated drugs. Always follow your doctor’s advice.

Stendra should not be taken with nitrates or certain blood pressure medications. Tell your healthcare provider about all medicines you take to avoid dangerous interactions.

Stendra is taken as needed before sexual activity. If you miss a dose, do not double up. Take it only when you plan to be sexually active and follow the dosing instructions carefully.

Yes. Avoiding alcohol, staying hydrated, and managing stress can help reduce side effects such as headaches and flushing.

Stendra typically starts working within 15 to 30 minutes and lasts for about 6 hours. Timing your dose correctly can help reduce side effects.

References

The Bottom Line

Most reactions are mild and temporary, but immediate medical attention is crucial for chest pain, vision changes, or prolonged erections. Starting with the lowest effective dose and avoiding alcohol significantly reduces your risk of complications. If you're experiencing concerning symptoms after taking Stendra, Doctronic can help you determine whether you need emergency care or can manage symptoms at home.

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