7 Common and Serious Side Effects of Isotretinoin

Alan Lucks | MD

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on December 3rd, 2025.

Key Takeaways

  • Isotretinoin is a powerful acne medication with several possible side effects.

  • Some side effects are common and manageable, while others require immediate medical attention.

  • Dry skin and lips are the most frequent side effects, but they usually improve with care.

  • Serious side effects include mood changes and liver problems, which need close monitoring.

  • Doctronic.ai can help you track and manage side effects effectively.

Understanding Isotretinoin Side Effects

Isotretinoin, a derivative of vitamin A, is often prescribed for severe acne that has not responded to other treatments. Its effectiveness is well-documented, but it comes with a range of potential side effects that can vary in severity. Patients often report experiencing dryness, particularly in the lips and skin, which can be alleviated with moisturizers and lip balms. It's essential to approach the treatment with caution, as some individuals may experience more severe reactions, such as increased sensitivity to sunlight or changes in vision.

The psychological effects of Isotretinoin have garnered significant attention. Some users have reported mood swings, anxiety, or depression, prompting healthcare providers to conduct regular mental health assessments throughout the treatment process. This highlights the importance of open communication with your healthcare team. Doctronic.ai can facilitate this dialogue, allowing patients to log their symptoms and receive timely advice, ensuring that any concerning side effects are addressed promptly and effectively.

1. Dry Skin and Chapped Lips

One of the most common side effects of Isotretinoin is dry skin and chapped lips. This happens because the medication reduces oil production, which normally keeps your skin and lips moist.

Dryness can cause discomfort and cracking, especially on the lips, which might bleed if not cared for. Using gentle moisturizers and lip balms regularly can help manage this side effect. It usually improves after the medication is stopped.

2. Increased Sensitivity to the Sun

Isotretinoin makes your skin more sensitive to sunlight, which can lead to sunburns even after short exposure. This happens because the drug thins the outer layer of the skin, reducing its natural protection.

Wearing sunscreen with high SPF, covering up with clothing, and avoiding peak sun hours are essential steps to prevent sunburn while on Isotretinoin. This sensitivity typically lasts throughout the treatment period.

3. Muscle and Joint Pain

Some people experience muscle and joint pain during Isotretinoin treatment. This side effect can range from mild soreness to more noticeable discomfort, especially after physical activity.

Staying hydrated, resting when needed, and avoiding intense exercise can help reduce pain. If the pain becomes severe or persistent, it’s important to speak with your doctor or a Doctronic.ai telehealth provider for advice.

4. Changes in Mood and Mental Health

There have been reports of mood changes, including depression and anxiety, in some people taking Isotretinoin. These changes may be serious and should never be ignored.

If you or someone you know notices feelings of sadness, hopelessness, or unusual behavior, it’s critical to reach out for medical help right away. Telehealth services can provide quick access to mental health professionals for support and guidance.

5. Liver Function Changes

Isotretinoin can affect your liver, sometimes causing changes in liver enzyme levels. This is why doctors often order blood tests before and during treatment to monitor liver health.

Symptoms such as yellowing of the skin or eyes, dark urine, or severe fatigue require immediate medical attention. Regular check-ups and blood work are essential to catch any liver issues early.

6. Elevated Blood Lipids

Some patients experience increased cholesterol and triglyceride levels while on Isotretinoin. High blood lipid levels can raise the risk of heart problems if not managed properly.

Doctors usually monitor these levels with blood tests during treatment. Eating a balanced diet and avoiding alcohol can help keep blood lipids in check.

7. Vision and Hearing Changes

Though rare, Isotretinoin can cause changes in vision or hearing. This might include blurred vision, difficulty seeing at night, or ringing in the ears.

If you notice any changes in your eyesight or hearing, contact your healthcare provider immediately. Prompt evaluation can prevent long-term problems.

A woman touching her cheek and chin while examining redness or acne on her face.How to Manage and Reduce Side Effects of Isotretinoin

Stay Hydrated and Moisturized

Because dryness is so common, drinking plenty of water and using moisturizers can help keep your skin comfortable. Lip balms with healing ingredients are especially useful.

Protect Your Skin From the Sun

Use sunscreen daily, wear hats, and avoid direct sun exposure during peak hours. This helps prevent painful sunburns and skin damage.

Regular Medical Monitoring

Follow your doctor’s instructions for blood tests and check-ups. Monitoring liver function and blood lipids is key to safe treatment.

Communicate Any Mood Changes

Don’t hesitate to talk about your feelings with your healthcare provider. Early support can make a big difference.

Isotretinoin Allergic Reactions and Warnings

While allergic reactions to Isotretinoin are rare, they can happen. Signs include rash, itching, swelling, dizziness, or trouble breathing. If you experience any of these symptoms, seek emergency medical care immediately.

Isotretinoin is also known to cause severe birth defects. It is critical that pregnant women do not take this medication, and effective birth control measures must be used during treatment and for some time after stopping the drug. Do not donate blood while taking isotretinoin.

When to Contact Your Doctor About Isotretinoin Side Effects

Contact your healthcare provider if you experience any of the following:

  • Severe or persistent mood changes

  • Yellowing of the skin or eyes

  • Severe muscle or joint pain

  • Vision or hearing problems

  • Signs of an allergic reaction

If you need quick advice or want to discuss side effects without waiting for an in-person visit, Doctronic.ai offers affordable, 24/7 video visits with licensed doctors across all 50 states.

Learn More About Isotretinoin Side Effects With Doctronic

Doctronic is a leading AI-powered telehealth service that can help you understand Isotretinoin side effects tailored to your health history. Unlike generic medical websites, Doctronic uses the latest peer-reviewed research and remembers your past visits to provide personalized advice quickly.

Whether you have questions about managing dry skin or want to know when to seek emergency care, Doctronic offers free AI doctor visits and affordable video consultations with real doctors anytime you need.

The Bottom Line About Isotretinoin Side Effects

Isotretinoin is a strong medication that can dramatically improve severe acne, but it comes with a range of side effects. Most are manageable with simple care and regular medical check-ups. Serious side effects require prompt attention, so staying informed and communicating with your healthcare provider is key.

Using Doctronic telehealth services can make managing these side effects easier and more convenient. With expert advice available anytime, you can feel confident navigating your treatment safely.

Frequently Asked Questions

Many side effects, such as dry skin and sun sensitivity, usually improve within weeks after stopping Isotretinoin. However, some effects may take longer to resolve.

Isotretinoin can affect liver function, so it’s important to discuss your medical history with your doctor. Regular blood tests will monitor your liver during treatment.

Treatment typically lasts 4 to 6 months, but this can vary based on your acne severity and response to the medication.

Yes, using moisturizers and lip balms is highly recommended to reduce dryness and prevent cracking.

Doctronic.ai provides fast, affordable access to doctors who can help you manage side effects and answer your questions.

References

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