What Happens When You Stop Taking Glucocorticoids?
Published: Oct 11, 2023
Medically reviewed by Angel Kerney | MD, F.A.C.O.G Obstetrics & Gynecology on October 11th, 2023.
Glucocorticoids are powerful drugs used to treat various inflammatory conditions, but stopping them can be tricky. This article explores what you need to know about withdrawing from glucocorticoids safely.
Contents
Why Withdraw Glucocorticoids?
Glucocorticoids are often withdrawn when maximum benefits are achieved, or when side effects like osteoporosis become too serious. In some cases, immediate cessation is necessary, such as in steroid-induced acute psychosis or herpesvirus-induced corneal ulceration. In these scenarios, using the lowest possible dose until safe withdrawal is crucial.
The Risk of HPA Suppression
Long-term use of glucocorticoids can suppress the hypothalamic-pituitary-adrenal (HPA) axis, making sudden withdrawal risky. Symptoms of adrenal insufficiency may appear if glucocorticoids are stopped too quickly. Patients with suspected HPA suppression should taper gradually and carry emergency medical information.
Tapering Approaches
Tapering glucocorticoids involves reducing doses gradually to prevent disease flare-ups and cortisol deficiency symptoms. A generally safe approach is to decrease the dose by 5-10% every one to four weeks, adjusting based on patient response. In some cases, an alternate-day regimen is used, but this might not suit everyone, especially those with rheumatoid arthritis.
Frequently Asked Questions
Withdrawal is needed to prevent side effects and manage conditions effectively.
HPA suppression occurs when glucocorticoids suppress adrenal gland function.
Symptoms can be managed by gradually tapering the medication dose.
It's a method of taking glucocorticoids every other day to reduce side effects.
Key Takeaways
Glucocorticoid withdrawal must be managed carefully to avoid complications.
Talk to Doctronic about the best way to taper off glucocorticoids safely.Related Articles
References
Kirwan JR. Systemic corticosteroids in rheumatology. In: Rheumatology, Hochberg MC, Silman AJ, Smolen JS (Eds), Mosby, St. Louis 2003. p.385.
Joseph RM, Hunter AL, Ray DW, Dixon WG. Systemic glucocorticoid therapy and adrenal insufficiency in adults: A systematic review. Semin Arthritis Rheum 2016; 46:133.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.