Sulfonylureas: The Unsung Heroes of Diabetes Treatment?
Published: Nov 20, 2023
Sulfonylureas are an effective and affordable medication for treating type 2 diabetes. While newer drugs often get more attention, sulfonylureas remain a key tool for managing blood sugar levels in many patients worldwide.
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How Do Sulfonylureas Work?
Sulfonylureas work by stimulating the pancreas to release more insulin. They bind to special receptors on pancreatic cells, causing them to open channels that allow insulin to be secreted. This helps lower blood sugar levels throughout the day. Think of sulfonylureas as a key that unlocks the pancreas's insulin stores.
When Are Sulfonylureas Used?
Doctors often prescribe sulfonylureas when metformin alone isn't enough to control blood sugar. They may also be used as a first treatment if metformin can't be taken. Sulfonylureas are especially useful for patients who need an affordable option. However, they're generally not combined with insulin due to the risk of low blood sugar.
Benefits and Risks
Sulfonylureas are very effective at lowering blood sugar levels, typically reducing A1C by 1-2%. They're also among the least expensive diabetes medications available. However, they can cause weight gain and low blood sugar (hypoglycemia). Newer, shorter-acting sulfonylureas like glipizide may have a lower risk of these side effects compared to older ones like glyburide.
Frequently Asked Questions
They start working within hours and reach full effect in a few days.
Yes, many patients use them safely for years with proper monitoring.
They can cause modest weight gain in some patients.
Recent studies show no increased cardiovascular risk with modern sulfonylureas.
Key Takeaways
While newer diabetes drugs often grab headlines, sulfonylureas remain an effective and affordable option for many patients when used appropriately.
Wondering if a sulfonylurea might be right for you? Ask Doctronic about how these medications fit into modern diabetes care.Related Articles
References
UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352:837.
Hirst JA, Farmer AJ, Dyar A, et al. Estimating the effect of sulfonylurea on HbA1c in diabetes: a systematic review and meta-analysis. Diabetologia 2013; 56:973.
Always discuss health information with your healthcare provider.