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Prednisone: The Good, The Bad, and The Tapering
Published: Mar 17, 2024
Prednisone is a common glucocorticoid drug used to tame inflammation, but its use requires careful consideration. This piece dives into how prednisone works and the challenges of stopping it.
Understanding Prednisone
Prednisone is a powerful anti-inflammatory medication that helps control symptoms in various diseases like rheumatoid arthritis and lupus. It is available in different forms, including tablets and injectables. Prednisone is inactive by itself and converts to prednisolone in the liver, which is the active form.
Potential Side Effects
While prednisone is effective, it can cause serious side effects if used long-term, such as osteoporosis and hypertension. These side effects often necessitate a reduction in dosage as soon as the condition is under control. In some cases, side effects can be severe enough to require immediate cessation of the drug.
Challenges in Tapering
Tapering off prednisone can be complicated due to differences in individual responses. Some people may experience withdrawal symptoms or a return of their disease symptoms. This process must be personalized, often involving slow, gradual reduction of the dose.
Frequently Asked Questions
Prednisone is used to treat inflammatory conditions like arthritis and lupus.
Common side effects include osteoporosis, hypertension, and mood changes.
Tapering is needed to prevent withdrawal symptoms and avoid disease flare-ups.
Prednisone reduces inflammation by suppressing the immune system.
Sudden cessation can cause adrenal insufficiency and worsening of symptoms.
Key Takeaways
Prednisone is effective but requires careful management to minimize risks.
References
- Francisco GE, Honigberg IL, Stewart JT, et al. In vitro and in vivo bioequivalence of commercial prednisone tablets. Biopharm Drug Dispos 1984; 5:335.
- Garg DC, Wagner JG, Sakmar E, et al. Rectal and oral absorption of methylprednisolone acetate. Clin Pharmacol Ther 1979; 26:232.
- Rose JQ, Yurchak AM, Jusko WJ, Powell D. Bioavailability and disposition of prednisone and prednisolone from prednisone tablets. Biopharm Drug Dispos 1980; 1:247.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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