How Are Intralesional Corticosteroid Injections Performed?
Published: Sep 16, 2023

Medically reviewed by Oghenefejiro Okifo | MD, Harvard Medical School | Henry Ford Hospital - Detroit, MI on September 16th, 2023.
Intralesional corticosteroid injections are a precise medical procedure used to treat certain skin conditions. Here's a step-by-step guide on how they are performed.
Contents
Preparation and Equipment
Before performing the injection, the clinician prepares the necessary equipment: a 1 mL Luer lock syringe, a 30- or 27-gauge needle, and the corticosteroid solution. The skin is cleaned with alcohol, and the solution is mixed just before use to ensure even suspension.
Injection Technique
The needle is inserted at a 45 to 90-degree angle into the lesion, aiming for the mid-dermis layer where most inflammatory changes occur. The clinician carefully injects the corticosteroid, ensuring the skin blanches slightly, indicating correct placement.

Post-Injection Care
After the injection, gauze is placed over the site to stop any bleeding, and an adhesive bandage may be applied if needed. Hand hygiene is crucial, and needles are disposed of in puncture-resistant containers to prevent accidental injury.
Frequently Asked Questions
The mid-dermis layer of the skin is the target area.
A 1 mL syringe and a 30- or 27-gauge needle are used.
Blanching indicates correct placement of the injection.
Gauze is applied, and hygiene protocols are followed.
Key Takeaways
Understanding the procedure can ease concerns—are you ready for your treatment?
Consult with Doctronic to learn more about this procedure and its benefits.Related Articles
References
HOLLANDER A. Intralesional injections of triamcinolone acetonide; a therapy for dermatoses. Antibiotic Med Clin Ther (New York) 1961; 8:78.
Callen JP. Intralesional corticosteroids. J Am Acad Dermatol 1981; 4:149.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.