Could Your Medication Be the Culprit for Low Magnesium?
Published: Jan 27, 2024
Some medications can cause a drop in magnesium levels, leading to unwanted side effects.
Contents
Medications That Affect Magnesium
Certain medications, such as diuretics and proton pump inhibitors, are known to affect magnesium levels. They can either increase the excretion of magnesium or inhibit its absorption. Understanding the impact of these drugs is crucial for managing and preventing hypomagnesemia.
The Role of Proton Pump Inhibitors
Proton pump inhibitors (PPIs), commonly used for acid-related issues, have been linked to lower magnesium levels. Chronic use, especially when combined with diuretics, can exacerbate this effect. Monitoring magnesium levels in patients using these medications long-term is essential.

Managing Medication-Induced Hypomagnesemia
For patients experiencing low magnesium due to medication, supplementation can be effective. Adjusting medication dosages or switching to alternatives may also help. Regular check-ups and lab tests are recommended for those at risk.
Frequently Asked Questions
Diuretics and proton pump inhibitors can lower magnesium levels.
Yes, chronic PPI use can inhibit magnesium absorption.
Supplementation and medication adjustments can help manage the condition.
Key Takeaways
Being aware of medication effects on magnesium can prevent potential health issues.
References
- Broeren MA, Geerdink EA, Vader HL, van den Wall Bake AW. Hypomagnesemia induced by several proton-pump inhibitors. Ann Intern Med 2009; 151:755.
- Danziger J, William JH, Scott DJ, et al. Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int 2013; 83:692.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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