Can Antisecretory Therapy Cure Refractory Ulcers?
Can Antisecretory Therapy Cure Refractory Ulcers?
The Big Picture
Antisecretory therapy is a cornerstone in managing stubborn peptic ulcers. Discover how these treatments work and why they're so crucial.
Contents
- How Antisecretory Therapy Works
- When Standard Doses Fail
- Exploring New Treatments
How Antisecretory Therapy Works
Antisecretory therapy involves medications that reduce stomach acid, helping ulcers heal. Proton pump inhibitors (PPIs) are often used, and they work by blocking the enzyme responsible for acid production. This reduction in acid allows the ulcerated tissue to repair and heal over time.
When Standard Doses Fail
Sometimes, standard doses of PPIs aren't enough to heal stubborn ulcers. In such cases, increasing the dose to twice daily can be effective. This approach helps ensure that acid levels remain low throughout the day, providing a better environment for healing.
Exploring New Treatments
In some cases, newer medications like potassium competitive acid inhibitors, such as vonoprazan, have shown promise. These drugs offer potent acid suppression and may be effective where traditional PPIs fail. However, their availability may vary by region.
FAQs
What is antisecretory therapy?
It's a treatment that reduces stomach acid to help ulcers heal.
What if standard doses don't work?
Increasing the dose to twice daily can help.
Are there new treatments available?
Yes, newer drugs like vonoprazan are being explored.
The Bottom Line
Antisecretory therapy remains a key player in the successful management of refractory peptic ulcers.
Additional References
- Bardhan KD. Aliment Pharmacol Ther 1993; 7 Suppl 1:13.
- Kawai T, Oda K, Funao N, et al. Gut 2018; 67:1033.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic.