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Bisphosphonates: The First Line of Defense Against Steroid-Induced Bone Loss
Published: Jan 11, 2024
Bisphosphonates are powerful medications that can help protect your bones from the damaging effects of long-term steroid use. These drugs are often the first choice for preventing and treating glucocorticoid-induced osteoporosis.
How Do They Work?
Bisphosphonates work by slowing down the cells that break down bone (osteoclasts). This allows the bone-building cells (osteoblasts) to catch up, helping to maintain or even increase bone density. Think of it like slowing down demolition crews while construction teams rebuild a city.
Types of Bisphosphonates
There are several types of bisphosphonates available. Alendronate and risedronate are commonly prescribed pills taken weekly. For those who can't tolerate oral medications, zoledronic acid is given as an annual intravenous infusion. Your doctor will help choose the best option based on your needs and preferences.
Effectiveness and Safety
Studies show that bisphosphonates can significantly reduce the risk of fractures in people taking glucocorticoids. They're generally safe, but like all medications, they can have side effects. The most common are stomach upset and heartburn with oral forms. Rare but serious side effects include jaw problems and unusual thigh bone fractures.
Frequently Asked Questions
Treatment duration varies, but is often reassessed after 3-5 years.
Yes, but timing matters. Ask your doctor for specific instructions.
No, they're not recommended for women who are or may become pregnant.
Weigh Your Options
Bisphosphonates can be a powerful tool in protecting your bones, but they're not right for everyone.
References
- Allen CS, et al. Bisphosphonates for steroid-induced osteoporosis. Cochrane Database Syst Rev 2016; 10:CD001347.
- Saag KG, et al. Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. N Engl J Med 1998; 339:292.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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