Are You at Risk? Symptoms of Warfarin Side Effects
Published: Nov 12, 2023
Warfarin is a powerful medication, but it can come with some serious side effects. Let's explore the symptoms you need to watch out for.
Bleeding Risks
One of the most common and serious side effects of warfarin is bleeding. This includes easy bruising, prolonged bleeding from cuts, and more serious issues like internal bleeding. Patients must be alert to signs of unusual bleeding and report them to their healthcare provider immediately.
Skin Changes
A rare but serious side effect is skin necrosis, where parts of the skin die off. It usually occurs within the first few days of treatment and appears as dark or purple patches. Immediate medical attention is necessary if such symptoms occur.

Other Symptoms
Warfarin can also cause cholesterol embolization, leading to purple toe syndromeβa condition where toes turn purple and painful. Additionally, allergic reactions, although rare, can manifest as rashes or itching. It's crucial to contact a healthcare provider if any unusual symptoms arise.
Frequently Asked Questions
The primary risk is bleeding due to its blood-thinning effects.
Yes, it can cause skin necrosis, a serious condition requiring immediate care.
It's a rare side effect where toes turn purple due to cholesterol embolization.
Allergic reactions are rare but can occur, usually presenting as a rash.
The Bottom Line
Being aware of warfarin's side effects can save you from serious health issues.
References
- Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy. Chest 2012; 141:e152S.
- Belley-Cote EP, Hanif H, D'Aragon F, et al. Genotype-guided versus standard vitamin K antagonist dosing algorithms. Thromb Haemost 2015; 114:768.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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