Are Systemic Therapies the Key to Ending Your Itch?
Published: Nov 23, 2023

Medically reviewed by Alan Lucks | MD, Alan Lucks MDPC Private Practice - New York on November 23rd, 2023.
When topical treatments just aren't cutting it, systemic therapies might be your answer to finding relief from stubborn itches.
Contents
When to Consider Systemic Therapy
Systemic therapies are typically used when topical treatments aren't effective or practical. They are especially useful for severe cases of itch that affect sleep or daily life. Oral antihistamines are often the first line of treatment, providing relief by targeting the itch from within.
Types of Systemic Therapies
Common systemic therapies include oral antihistamines, anticonvulsants, and, in some cases, antidepressants. These treatments work by calming the nervous system or altering chemical reactions in the body that cause itching. The choice of therapy depends on the type and cause of the itch.

Balancing Benefits and Risks
While systemic therapies can be highly effective, they also come with potential risks and side effects. It's important to weigh these carefully with your healthcare provider to ensure the benefits outweigh any possible downsides. Monitoring and adjusting doses can help minimize side effects.
Frequently Asked Questions
Treatments that work throughout the entire body.
When topical treatments fail or aren't enough.
Antihistamines, anticonvulsants, and antidepressants.
Yes, potential side effects exist.
Key Takeaways
Systemic therapies can provide relief when other options fall short.
Get started: Consider a consultation with Doctronic to explore systemic options for your itch.Related Articles
References
Leslie TA, et al. Handb Exp Pharmacol 2015; 226:337.
Young TA, et al. J Dermatolog Treat 2009; 20:76.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.