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GI & Digestive

Why Does My Stomach Hurt After Taking Ibuprofen?

Faith Coleman

Medically reviewed by Faith Coleman, University of New Mexico School of Medicine on August 22nd, 2026.

Ibuprofen can irritate your stomach lining and reduce protective mucus production. This nonsteroidal anti-inflammatory drug (NSAID) blocks enzymes called COX-1 and COX-2, which normally help maintain the stomach's protective barrier. Without adequate protection, stomach acid can damage the stomach lining, causing pain, inflammation, bleeding, or ulcers. Studies show that 10-20% of regular NSAID users develop stomach problems. Taking ibuprofen with food, using the lowest effective dose, or switching to enteric-coated versions can reduce irritation. If stomach pain persists or you experience nausea, vomiting, or black stools, stop taking ibuprofen and consult a healthcare provider immediately.

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