What Does a Syphilis Rash Look Like?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
A syphilis rash typically appears as small, rough, red or reddish-brown spots on the palms and soles. This distinctive rash occurs during secondary syphilis, usually 3-6 weeks after the initial chancre heals. The spots are painless, non-itchy, and measure 2-10mm in diameter. Unlike many other rashes, syphilis rashes uniquely affect the palms of hands and bottoms of feet, areas where most skin conditions don't appear. The rash may also spread to the trunk, arms, and legs. Without treatment, this rash typically resolves on its own within 2-6 weeks, but the infection progresses to more serious stages affecting internal organs.
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