What Are the Dangers of Long-Term Omeprazole Use?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
Long-term omeprazole use beyond 12 months carries several significant health risks. The most concerning dangers include increased fracture risk, with studies showing up to 44% higher rates of hip fractures in long-term users. Chronic suppression of stomach acid can lead to magnesium deficiency, causing muscle weakness and irregular heart rhythms. Vitamin B12 deficiency develops in approximately 65% of users after 2 years, potentially causing neurological problems. Kidney disease risk increases by 20-50% with prolonged use. Additionally, reduced stomach acid allows harmful bacteria to flourish, increasing risks of pneumonia and C. difficile infections by 30-40%.
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