Semaglutide Long-Term Side Effects

Semaglutide's long-term side effects include persistent gastrointestinal issues, potential pancreatitis risk, and thyroid concerns. Studies show 15-20% of patients experience ongoing nausea and diarrhea beyond the initial 12-week adjustment period. More serious concerns include increased risk of medullary thyroid carcinoma, though this primarily affects patients with genetic predisposition. Pancreatitis occurs in approximately 0.2% of long-term users according to clinical trials. Some patients also report gallbladder problems, with gallstones developing in 1.5% of cases during extended use. Kidney function may decline in patients who become severely dehydrated from persistent vomiting.

Related Questions

• How long do semaglutide side effects typically last?

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