Does Lamotrigine Help with Anxiety?

Lamotrigine is not FDA-approved for anxiety disorders and is primarily used as an anticonvulsant and mood stabilizer. While some studies suggest lamotrigine may have anti-anxiety effects in people with bipolar disorder, research specifically for anxiety disorders remains limited. A 2019 systematic review found mixed evidence for lamotrigine's effectiveness in anxiety conditions. The medication works by stabilizing sodium channels in the brain, which may indirectly reduce anxiety symptoms in certain patients. However, first-line treatments for anxiety include SSRIs, SNRIs, and benzodiazepines, which have stronger evidence bases. If you're considering lamotrigine for anxiety, discuss the potential benefits and risks with your psychiatrist.