March 31, 2026 Dermatology

Can You Use Neosporin on an Open Wound?

Medically reviewed by Faith Coleman, University of New Mexico School of Medicine on August 23rd, 2026.

Yes, Neosporin can be used on minor open wounds, but only for short periods. This topical antibiotic ointment contains three active ingredients—neomycin, polymyxin B, and bacitracin—that help prevent bacterial infections in small cuts, scrapes, and burns. The FDA recommends using it for no more than 7 days, as prolonged use can lead to antibiotic resistance or allergic reactions. Studies show that 8-10% of people develop contact dermatitis (a rash) from neomycin. For deep wounds, puncture wounds, or animal bites, avoid Neosporin and seek medical attention instead. Clean the wound thoroughly before application and if spreading redness or swelling of the wound occur get medical attention. Neosporin may be used on small, superficial burns, but if the burn is large or blistering get medical attention. For deep wounds, puncture wounds, large wounds, or animal bites, avoid Neosporin and seek medical attention instead.