Can You Take Excedrin and Ibuprofen Together?
Medically reviewed by Linda Girgis | MD, Girgis Family Medicine on August 21st, 2026.
No, you should not take Excedrin and ibuprofen together without medical supervision. Both medications contain NSAIDs (nonsteroidal anti-inflammatory drugs) - Excedrin contains aspirin, while ibuprofen is itself an NSAID. Taking them simultaneously can increase your risk of stomach ulcers, bleeding, and kidney damage by up to 300%. The combination also raises the likelihood of cardiovascular complications. If you need additional pain relief beyond one medication, consult a healthcare provider who can recommend safe alternatives or adjust dosing schedules. They may suggest spacing the medications several hours apart or switching to a different pain management approach entirely.
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