Can You Take Aleve and Tylenol Together?

Many adults can take Aleve and Tylenol together for a short time, but the combination is not safe for everyone. These medications work differently: both can reduce pain, while Aleve also reduces inflammation. Their different actions mean they can sometimes be used together, but this does not make the combination appropriate for everyone. Aleve (naproxen) is an NSAID that blocks prostaglandin production, while Tylenol (acetaminophen) works through the central nervous system. For some types of short-term pain, using both may provide more relief than either medicine alone. Follow each product’s label and do not exceed 660 mg of over-the-counter Aleve or 3,000 mg of acetaminophen in 24 hours unless a clinician directs you otherwise. Check cold, flu, sleep, and prescription medicines for acetaminophen so you do not take it twice, and do not use Aleve with another NSAID such as ibuprofen unless a clinician advises it. Ask a healthcare professional before using these medicines if you have kidney, liver, heart, ulcer, or bleeding problems; take blood thinners or other regular medicines; drink alcohol heavily; are pregnant; or are unsure whether they are safe for you.