Contents
The Role of Diagnostic Tests in CML Management
Published: Feb 23, 2024
Diagnostic tests are crucial in managing Chronic Myeloid Leukemia (CML). This article highlights the key tests used for diagnosing and monitoring CML.
Essential Blood Tests
Complete blood count (CBC) and differential count are vital in diagnosing CML. These tests measure the levels of different blood cells and can indicate abnormalities. Elevated white blood cell counts often prompt further investigation for CML, making these tests a starting point for diagnosis.
Genetic Testing for the Philadelphia Chromosome
Identifying the Philadelphia chromosome is critical in confirming a CML diagnosis. This involves cytogenetic testing and polymerase chain reaction (PCR) to detect the BCR::ABL1 gene fusion. These tests are not only important for diagnosis but also for monitoring treatment response and disease progression.
Monitoring Disease Progression
Regular monitoring with molecular tests helps assess how well treatment is working. Quantitative PCR tests measure the level of BCR::ABL1 in the blood, guiding treatment adjustments. Early detection of changes in these levels can prevent disease progression and improve outcomes.
Frequently Asked Questions
A CBC measures the levels of different blood cells to detect abnormalities.
CML is diagnosed by detecting the Philadelphia chromosome with cytogenetic and PCR tests.
Regular monitoring helps assess treatment effectiveness and prevent disease progression.
Vital Insights
Diagnostic tests are key to effective CML management, guiding both diagnosis and treatment.
References
- Testoni N, Marzocchi G, Luatti S, et al. Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis. Blood 2009; 114:4939.
- Marin D, Ibrahim AR, Lucas C, et al. Assessment of BCR-ABL1 transcript levels at 3 months is the only requirement for predicting outcome for patients with chronic myeloid leukemia. J Clin Oncol 2012; 30:232.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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