The Essential Tests for Diagnosing Systemic Sclerosis
Published: Feb 09, 2024
Diagnosing systemic sclerosis requires a series of comprehensive tests to assess skin, lung, kidney, and cardiac involvement. Here's what you need to know.
Contents
Skin Assessment: Beyond the Surface
The modified Rodnan skin score (mRSS) is the go-to test for measuring skin involvement in systemic sclerosis. By evaluating skin thickness at 17 sites, doctors can monitor disease progression. This scoring system provides valuable insights into the severity and potential complications of the disease.
Checking Lung and Heart Health
Pulmonary function tests and echocardiograms are essential for detecting lung and heart issues in systemic sclerosis. High-resolution CT scans offer a clearer picture of lung health, while echocardiograms assess the risk of pulmonary hypertension. These tests help in early detection and management of serious complications.

Monitoring Kidney Function
Regular monitoring of blood pressure, serum creatinine, and glomerular filtration rate (GFR) is crucial in patients with systemic sclerosis. These tests help identify scleroderma renal crisis early on. Accurate assessment of kidney function ensures timely intervention and reduces the risk of severe complications.
Frequently Asked Questions
It measures skin thickness in systemic sclerosis.
They detect lung issues and guide treatment.
Through blood pressure, creatinine, and GFR tests.
It assesses heart risk, particularly pulmonary hypertension.
Wrapping Up
Comprehensive testing is key to effectively managing systemic sclerosis and preventing complications.
References
- Clements PJ, Hurwitz EL, Wong WK, et al. Skin thickness score as a predictor and correlate of outcome in systemic sclerosis: high-dose versus low-dose penicillamine trial. Arthritis Rheum 2000; 43:2445.
- Khanna D, Furst DE, Clements PJ, et al. Standardization of the modified Rodnan skin score for use in clinical trials of systemic sclerosis. J Scleroderma Relat Disord 2017; 2:11.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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