Pruritus, or itching, is a common symptom of cholestasis, a liver condition that blocks or slows down bile flow. This itch can range from mildly annoying to completely debilitating, affecting sleep and overall quality of life. Though the exact cause of the itch is unknown, several theories suggest it might be due to a build-up of bile acids, changes in nerve pathways, or other chemical imbalances in the body.

Pruritus can occur with various liver-related issues, including primary biliary cholangitis, primary sclerosing cholangitis, and even during pregnancy (intrahepatic cholestasis). It can also be a symptom of bile duct obstruction, chronic hepatitis, cirrhosis, or a side effect of certain medications. The frequency of itching varies across these conditions, with some like intrahepatic cholestasis of pregnancy being more prone to causing itchiness.

When a patient with liver dysfunction reports itching, doctors may suspect cholestasis-associated pruritus. Diagnosing this condition doesn't usually require extensive tests if the liver issue is known. However, a thorough skin examination is essential to rule out dermatologic causes like eczema or contact dermatitis.

Understanding the link between cholestasis and itching is crucial for effective management.