Contents
Who Is Most at Risk for Statin Muscle Pain?
Published: Apr 28, 2024
Statins are effective at lowering cholesterol, but they can cause muscle pain in some individuals. Learn about the risk factors that increase susceptibility to these side effects.
Genetic Predispositions
Genetic factors can significantly increase the risk of muscle pain from statins. Variants in the SLCO1B1 gene, which affects statin metabolism, are linked to higher risk. Understanding your genetic makeup can help tailor statin therapy to minimize side effects.
Concurrent Medications
Taking other medications that inhibit statin metabolism can increase muscle pain risk. Drugs that inhibit the CYP3A4 enzyme, such as certain antibiotics and antifungals, are known to increase this risk. Managing these interactions is crucial for minimizing side effects.
Personal Health Factors
Certain health conditions, like liver disease, kidney disease, and hypothyroidism, can increase the likelihood of experiencing statin muscle pain. Age, gender, and body composition also play roles, with older adults and women being more susceptible.
Frequently Asked Questions
Variants in the SLCO1B1 gene increase risk.
They can inhibit statin metabolism, increasing risk.
Older adults, women, and those with certain health conditions.
Key Takeaways
Understanding risk factors for statin muscle pain can lead to better management and prevention strategies.
References
- Brunham LR, Baker S, Mammen A, et al. Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence. Cardiovasc Res 2018; 114:1073.
- Voora D, Shah SH, Spasojevic I, et al. The SLCO1B1*5 genetic variant is associated with statin-induced side effects. J Am Coll Cardiol 2009; 54:1609.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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