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What You Need to Know About Familial Adenomatous Polyposis
Published: Nov 14, 2023
Familial adenomatous polyposis (FAP) is a serious genetic condition that can lead to cancer if not managed properly. Understanding its implications can help at-risk individuals take early preventive action.
The Basics of FAP
FAP is an inherited disorder caused by mutations in the APC gene, leading to the development of numerous colorectal polyps. These polyps, if untreated, can turn into cancer, making early detection and management crucial. The classic form of FAP can result in hundreds to thousands of polyps, while an attenuated form (AFAP) has fewer polyps and a later onset.
Screening and Diagnosis
Screening for FAP involves genetic testing and regular colonoscopies to monitor polyp development. Those with a family history or early signs of FAP should begin screening around age 10-15. The presence of specific symptoms or polyps can guide the frequency of screenings and subsequent medical actions.
Risks Beyond the Colon
FAP isn't limited to colorectal issues; it can also increase the risk of other cancers like thyroid and upper gastrointestinal cancers. Regular monitoring and specific tests such as thyroid ultrasounds are recommended to catch and manage these risks early.
Frequently Asked Questions
FAP is a genetic condition causing numerous colorectal polyps, leading to cancer if untreated.
FAP is diagnosed through genetic testing and regular colonoscopy screenings.
Yes, FAP can also increase the risk of thyroid and other cancers.
Screening should start around age 10-15 for those at risk.
Key Takeaways
Understanding and managing FAP early can significantly reduce cancer risks.
References
- Syngal S, Brand RE, Church JM, et al. ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
- Herraiz M, Barbesino G, Faquin W, et al. Prevalence of thyroid cancer in familial adenomatous polyposis syndrome.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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