What is Diabetic Polyneuropathy and Why Should You Care?

Understanding Diabetic Polyneuropathy

Diabetic polyneuropathy affects the peripheral nervous system, which includes nerves outside the brain and spinal cord. It is mainly characterized by nerve damage that usually starts in the feet and legs and can progress to the hands and arms. This condition is often associated with high blood sugar levels, which can lead to nerve fiber damage over time.

Pathology of Diabetic Neuropathy

Distal symmetric polyneuropathy, the most common form, involves a 'dying back' of axons, primarily affecting the longest sensory nerves. This results in numbness or pain, typically beginning in the feet. While the exact cause is complex, it's believed to involve both metabolic and vascular factors that lead to nerve damage.

Metabolic and Vascular Contributions

In diabetic polyneuropathy, excess glucose and lipids contribute to nerve damage. This metabolic overload can overwhelm the cells' energy production, leading to damage from reactive oxygen species. Additionally, vascular issues, such as reduced blood flow, can exacerbate nerve damage, creating a cycle of worsening symptoms.

Frequently Asked Questions

Key Takeaways

Understanding diabetic polyneuropathy is key to managing its symptoms and improving life quality.

Related Articles

• Are You at Risk for Diabetic Polyneuropathy?
• Can Diabetic Polyneuropathy Be Prevented?
• Guidelines for Managing Diabetic Polyneuropathy
• Recognizing the Signs: Symptoms of Diabetic Polyneuropathy

References