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What Increases Your Risk of Systemic Sclerosis?
Published: Jan 13, 2024
While the exact cause of systemic sclerosis remains unknown, researchers have identified several factors that may increase a person's risk of developing this condition. Let's explore what we know about these risk factors.
Genetic Factors: It's in the Family
While systemic sclerosis isn't directly inherited, having a family history of the disease or other autoimmune conditions can increase your risk. Certain genetic variations have been associated with a higher likelihood of developing systemic sclerosis, suggesting a genetic component to the disease.
Environmental Triggers: External Influences
Exposure to certain environmental factors may play a role in triggering systemic sclerosis in susceptible individuals. These can include exposure to silica dust, organic solvents, or certain drugs. Some studies have also suggested a possible link with viral infections, though this connection isn't fully understood.
Demographic Factors: Who's at Risk?
Systemic sclerosis is more common in women than in men, with a ratio ranging from 3:1 to 8:1. It typically develops between ages 30 and 50, though it can occur at any age. Some studies suggest that certain racial or ethnic groups may have a higher risk or experience more severe disease.
Frequently Asked Questions
Stress alone doesn't cause it, but may contribute to symptom flares.
No, it's not contagious and can't be spread from person to person.
While not direct causes, smoking and poor nutrition may influence disease course.
Pregnancy itself isn't a risk factor, but can complicate existing disease.
A Complex Picture
While these risk factors provide clues, the development of systemic sclerosis likely involves a complex interplay of genetic and environmental factors.
References
- Ingegnoli F, Ughi N, Mihai C. Update on the epidemiology, risk factors, and disease outcomes of systemic sclerosis. Best Pract Res Clin Rheumatol 2018; 32:223.
- Peoples C, Medsger TA Jr, Lucas M, et al. Gender differences in systemic sclerosis: relationship to clinical features, serologic status and outcomes. J Scleroderma Relat Disord 2016; 1:177.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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