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What Increases Your Risk for Hereditary Hemochromatosis?
Published: Apr 27, 2024
Identifying risk factors for hereditary hemochromatosis can help in early detection and management of the condition.
Genetic Risk Factors
The primary risk factor for HH is genetic, specifically inheriting two copies of the C282Y variant in the HFE gene. This genetic makeup significantly increases the likelihood of developing iron overload.
Environmental and Lifestyle Factors
While genetics play a major role, lifestyle factors such as high dietary iron intake and alcohol consumption can exacerbate iron overload. Environmental factors like infections or liver diseases may also influence iron levels.
Family History Considerations
Having a family member with HH increases your risk. Family history can guide genetic testing and monitoring for early signs of iron overload, especially in first-degree relatives.
Frequently Asked Questions
Inheriting two C282Y gene variants is the primary risk.
Yes, diet and alcohol can influence iron levels.
Yes, a family member with HH increases your risk.
Risk Awareness
Understanding your risk factors for hereditary hemochromatosis can lead to proactive health management.
References
- Grosse SD, Gurrin LC, Bertalli NA, Allen KJ. Clinical penetrance in hereditary hemochromatosis: estimates of the cumulative incidence of severe liver disease among HFE C282Y homozygotes. Genet Med 2018; 20:383.
- Kowdley KV, Brown KE, Ahn J, Sundaram V. ACG Clinical Guideline: Hereditary Hemochromatosis. Am J Gastroenterol 2019; 114:1202.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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