Contents
What Does Research Say About Glucocorticoid Side Effects?
Published: Sep 29, 2024
Recent studies shed light on the side effects of glucocorticoids, revealing important insights for safer use. Let's explore what the research says.
Dose and Duration Factors
Research indicates that the risk of glucocorticoid side effects is closely linked to the dosage and duration of treatment. Higher doses and longer use increase the likelihood of adverse effects such as osteoporosis, infections, and cardiovascular issues. These findings highlight the need for careful dosage management.
Genetic Variations and Individual Responses
Studies also reveal that genetic factors can affect an individual's response to glucocorticoids. Variations in glucocorticoid receptor genes may explain why some people experience more severe side effects than others. Understanding these genetic influences can lead to more personalized treatment plans.
Short-term Use Risks
Even short-term use of glucocorticoids can pose risks. Research has shown increased rates of infections and cardiovascular events shortly after starting therapy. This underscores the importance of monitoring even during brief treatment periods.
Frequently Asked Questions
Higher doses and longer use increase the risk.
Yes, genetic variations can influence side effects.
Yes, short-term use can increase infection risk.
Careful dosage management and monitoring help reduce risks.
Informed Decisions
Research insights are crucial for making informed decisions about glucocorticoid therapy.
References
- Schäcke H, Döcke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002; 96:23.
- Waljee AK, Rogers MA, Lin P, et al. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ 2017; 357:j1415.
- Yao TC, Huang YW, Chang SM, et al. Association Between Oral Corticosteroid Bursts and Severe Adverse Events : A Nationwide Population-Based Cohort Study. Ann Intern Med 2020; 173:325.
- Broersen LH, Pereira AM, Jørgensen JO, Dekkers OM. Adrenal Insufficiency in Corticosteroids Use: Systematic Review and Meta-Analysis. J Clin Endocrinol Metab 2015; 100:2171.
- George MD, Baker JF, Winthrop K, et al. Risk for Serious Infection With Low-Dose Glucocorticoids in Patients With Rheumatoid Arthritis : A Cohort Study. Ann Intern Med 2020; 173:870.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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