What Causes Cirrhosis? The Hidden Culprits
Published: Dec 24, 2023
Cirrhosis doesn't just happen overnight. Understanding its causes can help prevent or manage this serious condition.
Contents
Leading Causes
In the U.S., hepatitis C, alcohol-related liver disease, and non-alcoholic fatty liver disease are the leading causes of cirrhosis. Combined, these conditions account for a significant portion of those awaiting liver transplants.
Less Common Causes
Less common causes include autoimmune hepatitis, genetic disorders like Wilson disease, and prolonged use of certain medications. These conditions can silently damage the liver over time, eventually leading to cirrhosis.

Mysterious Etiologies
Some cases of cirrhosis arise from unknown causes, making diagnosis and treatment challenging. This underscores the importance of ongoing research and awareness.
Frequently Asked Questions
Hepatitis C is one of the most common causes.
Yes, long-term alcohol abuse is a major cause.
Yes, conditions like Wilson disease can lead to cirrhosis.
Certain medications, when used long-term, can contribute to cirrhosis.
Key Takeaways
Knowing what causes cirrhosis can help you take preventive measures and seek timely medical advice.
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References
Wong RJ, et al. Gastroenterology 2015; 148:547.
Heidelbaugh JJ, Bruderly M. Am Fam Physician 2006; 74:756.
Always discuss health information with your healthcare provider.