What Are the Risk Factors for Acquired von Willebrand Syndrome?
What Are the Risk Factors for Acquired von Willebrand Syndrome?
Identifying Risks
Acquired von Willebrand syndrome (AVWS) can arise due to various health conditions and treatments. Discover the key risk factors that can lead to the development of AVWS.
Contents
- Underlying Health Conditions
- Impact of Medical Devices
- Medications and Their Effects
Underlying Health Conditions
AVWS is often associated with other medical conditions such as lymphoproliferative disorders, autoimmune diseases like lupus, and cardiovascular issues like aortic stenosis. These conditions can alter the levels of von Willebrand factor, leading to bleeding issues.
Impact of Medical Devices
Certain medical devices, like left ventricular assist devices (LVADs) and extracorporeal membrane oxygenation (ECMO), can increase the risk of developing AVWS. The mechanical shear stress from these devices can damage VWF, making it less effective at controlling bleeding.
Medications and Their Effects
Medications such as valproic acid and certain antibiotics can also contribute to AVWS. These drugs might reduce VWF synthesis or increase its breakdown, leading to lower levels in the bloodstream and an increased risk of bleeding.
FAQs
What health conditions increase AVWS risk?
Conditions like lymphoproliferative disorders and autoimmune diseases increase AVWS risk.
Do medical devices affect AVWS?
Yes, devices like LVADs and ECMO can increase AVWS risk.
Can medications cause AVWS?
Some medications may contribute to AVWS by affecting VWF levels.
The Bottom Line
Recognizing the risk factors for AVWS is crucial for prevention and management.
Additional References
- Kumar S, Pruthi RK, Nichols WL. Acquired von Willebrand disease. Mayo Clin Proc 2002; 77:181.
- Mohri H. Acquired von Willebrand syndrome: features and management. Am J Hematol 2006; 81:616.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic.