What Are the Risk Factors for Acquired von Willebrand Syndrome?
Published: Jun 16, 2024
Acquired von Willebrand syndrome (AVWS) can arise due to various health conditions and treatments. Discover the key risk factors that can lead to the development of AVWS.
Contents
Underlying Health Conditions
AVWS is often associated with other medical conditions such as lymphoproliferative disorders, autoimmune diseases like lupus, and cardiovascular issues like aortic stenosis. These conditions can alter the levels of von Willebrand factor, leading to bleeding issues.
Impact of Medical Devices
Certain medical devices, like left ventricular assist devices (LVADs) and extracorporeal membrane oxygenation (ECMO), can increase the risk of developing AVWS. The mechanical shear stress from these devices can damage VWF, making it less effective at controlling bleeding.
Medications and Their Effects
Medications such as valproic acid and certain antibiotics can also contribute to AVWS. These drugs might reduce VWF synthesis or increase its breakdown, leading to lower levels in the bloodstream and an increased risk of bleeding.
Frequently Asked Questions
Conditions like lymphoproliferative disorders and autoimmune diseases increase AVWS risk.
Yes, devices like LVADs and ECMO can increase AVWS risk.
Some medications may contribute to AVWS by affecting VWF levels.
Key Takeaways
Recognizing the risk factors for AVWS is crucial for prevention and management.
Want to know your risk? Connect with Doctronic for a personalized assessment of AVWS risk factors.Related Articles
References
Kumar S, Pruthi RK, Nichols WL. Acquired von Willebrand disease. Mayo Clin Proc 2002; 77:181.
Mohri H. Acquired von Willebrand syndrome: features and management. Am J Hematol 2006; 81:616.
Always discuss health information with your healthcare provider.