Treating Mono: What Works and What Doesn't for Infectious Mononucleosis
Published: Jan 17, 2024
When it comes to treating infectious mononucleosis, or 'mono', the approach is more about managing symptoms than curing the virus. Understanding effective treatments can help you recover more comfortably and avoid complications.
Contents
Rest: Your Best Medicine
The cornerstone of mono treatment is rest. Your body needs time to fight the virus and recover. While complete bed rest isn't necessary, it's important to take it easy and get plenty of sleep. This may mean taking time off from school or work, especially in the early stages of illness.
Symptom Relief: Easing the Discomfort
Over-the-counter pain relievers like acetaminophen or ibuprofen can help with fever and sore throat. Gargling with salt water or using throat lozenges may also provide relief. Staying hydrated is crucial, so drink plenty of fluids. In some cases, your doctor might prescribe a corticosteroid if there's severe throat swelling.

What Doesn't Work: Myths and Misconceptions
Antibiotics like amoxicillin are ineffective against mono since it's caused by a virus, not bacteria. In fact, they can cause a rash in mono patients. Antiviral drugs like acyclovir, while effective against some viruses, haven't shown significant benefit for mono. There's also no evidence that special diets or supplements speed recovery.
Cautions and Complications
It's important to avoid contact sports and strenuous activities for several weeks to prevent splenic rupture, a rare but serious complication. Alcohol should also be avoided as it can stress the liver, which is often affected by mono. If symptoms worsen or new ones develop, consult your doctor promptly.
Frequently Asked Questions
Most recover in 2-4 weeks, but fatigue can last months.
Once fever subsides, it's usually okay if you feel up to it.
Rest, fluids, and gargling salt water can help ease symptoms.
Not strictly, but avoid kissing and sharing utensils.
Symptoms rarely recur, but the virus can reactivate.
The Road to Recovery
While mono treatment is mainly supportive, understanding what helps and what doesn't can make your recovery smoother.
References
- Luzuriaga K, Sullivan JL. Infectious mononucleosis. N Engl J Med 2010; 362:1993.
- Rea TD, Russo JE, Katon W, et al. Prospective study of the natural history of infectious mononucleosis caused by Epstein-Barr virus. J Am Board Fam Pract 2001; 14:234.
- Tynell E, Aurelius E, Brandell A, et al. Acyclovir and prednisolone treatment of acute infectious mononucleosis: a multicenter, double-blind, placebo-controlled study. J Infect Dis 1996; 174:324.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
AI Doctor Visit Required
Appointments available 24/7
15-min consultation. No hidden costs.
AI Doctor Visit Required
For safety reasons we have been forced to end this consultation.
If you believe this is a medical emergency please call 911 or your local emergency services immediately.
If you are experiencing emotional distress, please call the the Suicide & Crisis Lifeline at 988 or your local crisis services immediately.
Contact us
You can also email us at help@doctronic.ai
We aim to reply within 5-7 days
How likely are you to recommend Doctronic to friends or family?