Treating Familial Hypercholesterolemia: A Guide to Lowering Sky-High Cholesterol

Statins: The First Line of Defense

High-dose statin medications are the cornerstone of FH treatment. These drugs, like atorvastatin or rosuvastatin, work by reducing the liver's cholesterol production. For many FH patients, statins can lower LDL cholesterol by 50% or more. However, they're often not enough on their own to reach target cholesterol levels.

Beyond Statins: Additional Medications

When statins aren't enough, doctors add other cholesterol-lowering drugs. Ezetimibe blocks cholesterol absorption in the intestines. PCSK9 inhibitors, given as injections, dramatically boost the body's ability to remove LDL from the blood. For severe cases, drugs like lomitapide may be used, though they can have significant side effects.

LDL Apheresis: Filtering the Blood

Some FH patients, especially those with the more severe homozygous form, may need LDL apheresis. This procedure, similar to dialysis, filters LDL cholesterol directly from the blood. It's typically done every 1-2 weeks and can lower LDL levels by 60-70% each time.

Frequently Asked Questions

Key Takeaways

With proper treatment, people with FH can significantly reduce their risk of early heart disease and live long, healthy lives.

Related Articles

• What is Familial Hypercholesterolemia and Why Should You Care?
• Are You at Risk for Familial Hypercholesterolemia? Key Factors to Know
• Diagnosing Familial Hypercholesterolemia: From Blood Tests to Genetic Screening
• Managing Familial Hypercholesterolemia: Expert Guidelines for Patients and Doctors

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