The Medication Maze: Navigating Drugs for Frontotemporal Dementia
Published: Feb 18, 2024
Navigating the world of medications for frontotemporal dementia (FTD) can be daunting, but understanding their role is essential. This guide explores what works, what doesn't, and the potential risks involved.
Contents
The Role of Medications
While medications can offer some symptom relief in FTD, they are not a cure. SSRIs like citalopram and trazodone are often used to manage behavioral symptoms. However, these medications come with risks and should be used cautiously and under medical supervision.
Serotonergic Medications
SSRIs such as sertraline and paroxetine are used to decrease anxiety and impulsivity in FTD patients. Despite limited evidence from controlled trials, these medications are frequently employed based on observational data. Careful dose management and monitoring for side effects are crucial during treatment.

The Last Resort: Antipsychotics
Antipsychotic medications, like quetiapine, are considered only when other treatments fail. They can help with agitation but carry significant risks, including increased mortality. Patients and families should be made aware of these risks before starting treatment.
Frequently Asked Questions
No, medications cannot cure FTD.
Citalopram and trazodone are commonly used.
Antipsychotics carry risks and should be used as a last resort.
SSRIs mainly target behavioral symptoms.
Antipsychotics can increase mortality risk in dementia patients.
The Bottom Line
While medications can help manage FTD symptoms, they come with risks and require careful oversight.
References
- Huey ED, Putnam KT, Grafman J. A systematic review of neurotransmitter deficits and treatments in frontotemporal dementia. Neurology 2006; 66:17.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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