Spot Check: When to Biopsy a Mole
Published: May 28, 2024
Not all moles need a biopsy, but certain signs could indicate a necessity. Discover when to take action and why a biopsy is crucial.
Contents
Signs That Demand Attention
Moles with features like asymmetry, irregular borders, or multiple colors might need a closer look. A sudden change in size or appearance can also be a red flag. These are essential indicators for when a biopsy might be necessary.
Special Cases: Nevi in Unusual Locations
Moles on the palms, soles, or nail matrix can be more concerning and may warrant a biopsy. These locations are less common for benign moles but can be sites for melanoma. Monitoring changes in these areas is critical.

Technique Matters: How Biopsies Are Done
When a biopsy is performed, ensuring the entire mole is examined is vital. This allows for accurate diagnosis and ensures that any suspicious features are thoroughly evaluated. Providing detailed information to the pathologist can aid in the diagnosis.
Frequently Asked Questions
If it shows atypical features or changes rapidly.
Not all, but those with unusual features may need a biopsy.
Removing the entire mole for examination.
The Bottom Line
Timely biopsies can be lifesaving by catching skin cancer early.
References
- Scope A, Marchetti MA, Marghoob AA, et al. The study of nevi in children: Principles learned and implications for melanoma diagnosis. J Am Acad Dermatol 2016; 75:813.
- Aouthmany M, Weinstein M, Zirwas MJ, Brodell RT. The natural history of halo nevi: a retrospective case series. J Am Acad Dermatol 2012; 67:582.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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