Contents
Scratching the Surface: Effective Treatments for Cholestasis-Induced Itching
Published: Nov 21, 2023
Pruritus from cholestasis can be debilitating, but there are treatments that can help. This article explores various therapies to alleviate the relentless itch.
Simple Soothers for Mild Itch
For mild cases of pruritus, non-specific treatments like warm baths or emollients can offer relief. Antihistamines might help, especially if the itch is keeping you awake at night. However, these measures often fall short when dealing with moderate to severe symptoms.
Pharmacological Warriors
When the itch persists, medications come into play. Bile acid sequestrants, like cholestyramine, are often the first line of treatment, followed by rifampin if needed. If these don't work, opioid antagonists such as naltrexone can be considered. Each of these drugs works differently to tackle the itch at its root.
Alternative Options
In cases where standard treatments fail, other options like sertraline or phenobarbital may be tried. In severe cases, liver transplantation might be the only solution. Emerging therapies, such as ileal bile acid transport inhibitors, are also being explored for their potential benefits.
Frequently Asked Questions
Bile acid sequestrants like cholestyramine are often used first.
Alternatives like sertraline or phenobarbital might be tried.
Yes, warm baths and emollients can soothe mild cases.
Yes, novel therapies like ileal bile acid transport inhibitors are being studied.
Finding Relief
Effective management of cholestasis-induced pruritus is possible with the right treatment plan.
References
- Lindor KD, et al. Primary biliary cholangitis: 2021 practice guidance update. Hepatology 2022; 75:1012.
- Tandon P, et al. Efficacy and safety of bile Acid binding agents. Am J Gastroenterol 2007; 102:1528.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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