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Risk Factors for Bleeding in Hemophilia: What Increases Your Risk?
Published: Oct 24, 2023
Understanding the risk factors that contribute to bleeding in hemophilia can help in managing the condition effectively. This article highlights key risk factors that increase bleeding risk.
Genetic Factors
The primary risk factor for hemophilia is its genetic nature. Hemophilia is an inherited X-linked disorder, so males are predominantly affected. Female carriers can also experience symptoms if their clotting factor levels are low. The specific genetic mutation can influence the severity of the disease and the risk of developing inhibitors.
Severity of Hemophilia
The severity of hemophilia is categorized based on the percentage of normal clotting factor activity. Those with severe hemophilia (<1% activity) are at a higher risk of spontaneous bleeding compared to those with mild or moderate forms. The level of factor activity correlates directly with bleeding risk and frequency.
Presence of Inhibitors
Inhibitors are antibodies that can develop in response to factor replacement therapy, complicating treatment. Patients with inhibitors face an increased risk of uncontrolled bleeding and may require alternative therapies. The presence of inhibitors is a significant risk factor for bleeding complications.
Frequently Asked Questions
The main risk factor is its genetic, X-linked inheritance.
Severe hemophilia increases the risk of spontaneous bleeding.
Inhibitors are antibodies that neutralize clotting factors, increasing bleeding risk.
The Bottom Line
Recognizing risk factors helps in tailoring effective hemophilia management plans.
References
- Blanchette VS, et al. Definitions in hemophilia: communication from the SSC of the ISTH. J Thromb Haemost 2014; 12:1935.
- White GC 2nd, et al. Definitions in hemophilia. Thromb Haemost 2001; 85:560.
- Franchini M, et al. Mild hemophilia A. J Thromb Haemost 2010; 8:421.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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