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Peptic Ulcers: What Really Causes Them?
Published: Jan 01, 2024
Understanding what causes peptic ulcers can help prevent them. Let's uncover the main culprits behind this common ailment.
The Role of H. Pylori
Helicobacter pylori, or H. pylori, is a bacteria found in many people’s stomachs. It can lead to inflammation and, eventually, ulcers. Testing for and treating H. pylori is crucial in managing peptic ulcer disease because eradicating this bacteria can prevent ulcers from coming back.
Medicines That Might Be Harmful
Nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen are common pain relievers that can irritate the stomach lining. Long-term or heavy use increases the risk of developing ulcers. Corticosteroids, especially when combined with NSAIDs, can also heighten this risk.
Other Unusual Causes
While less common, certain systemic diseases like sarcoidosis or Crohn's disease can also lead to peptic ulcers. In these cases, the ulcers are a result of the primary disease affecting the stomach lining. Biopsies and other diagnostic tests help identify these rarer causes.
Frequently Asked Questions
H. pylori infection is a leading cause of peptic ulcers.
Yes, NSAIDs like aspirin and ibuprofen can lead to ulcers.
Yes, certain diseases like Crohn's can also cause ulcers.
Through tests like urea breath tests or stool antigen assays.
The Bottom Line
Knowing the causes of peptic ulcers can aid in prevention and treatment.
References
- Malfertheiner P, Megraud F, O'Morain CA, et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut 2017; 66:6.
- Tseng CL, Chen YT, Huang CJ, et al. Short-term use of glucocorticoids and risk of peptic ulcer bleeding: a nationwide population-based case-crossover study. Aliment Pharmacol Ther 2015; 42:599.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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