Navigating MS Treatment: A Guide to Choosing the Right Oral Medication
Published: Sep 16, 2023
With multiple oral medications now available for MS, choosing the right treatment can be overwhelming. This guide will help you understand the factors to consider when selecting an oral MS drug.
Contents
Assess Your MS Type and Activity
The first step in choosing an MS medication is understanding your specific type of MS and how active your disease is. Most oral drugs are approved for relapsing forms of MS, including clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and active secondary progressive MS (SPMS). Your doctor will consider factors like how frequently you have relapses and whether you have new lesions on MRI scans.
Consider Your Health Profile
Your overall health and any other medical conditions play a crucial role in medication selection. Some MS drugs may not be suitable if you have heart problems, liver disease, or a history of certain infections. Pregnancy plans are another important consideration, as some medications can harm a developing fetus. Be sure to discuss your full medical history and future health goals with your healthcare team.

Weigh Efficacy vs Side Effects
Different oral MS medications have varying levels of effectiveness and side effect profiles. Some drugs, like fingolimod, may be more potent but also carry higher risks. Others, like teriflunomide, might have a more moderate effect but could be better tolerated. Your doctor can help you balance the potential benefits against the risks for your individual situation. Consider which side effects you're most concerned about and which you feel you could manage.
Factor in Lifestyle and Preferences
Think about how different medications might fit into your daily life. Some require daily dosing, while others have different schedules. Consider factors like your ability to remember to take pills regularly, your comfort with regular medical monitoring, and how the potential side effects might impact your work or social life. Don't hesitate to express your preferences to your healthcare team.
Frequently Asked Questions
Yes, but switching should be done carefully under medical supervision.
Newer doesn't always mean better - effectiveness and safety vary by individual.
It can take several months to fully evaluate a medication's effectiveness.
Coverage varies, but many insurers do cover oral MS drugs with proper documentation.
Some drug interactions are possible, so always inform your doctor about all medications.
A Personalized Approach
Choosing an MS medication is a highly individual process that requires careful consideration of multiple factors.
References
- Derfuss T, et al. Advances in oral immunomodulating therapies in relapsing multiple sclerosis. Lancet Neurol 2020; 19:336.
- McGinley MP, Cohen JA. Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions. Lancet 2021; 398:1184.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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