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Natalizumab: A Game Changer for MS?
Published: Feb 08, 2024
Natalizumab is a powerful drug for managing multiple sclerosis, but what makes it so effective, and what should patients watch out for?
How Natalizumab Works
Natalizumab is a monoclonal antibody that targets integrin molecules to prevent immune cells from entering the brain and spinal cord. By doing so, it reduces inflammation and nerve damage associated with MS, helping to decrease relapses and slow disease progression. This makes it an attractive option for patients with active relapsing forms of MS.
Administration and Dosage
Natalizumab is delivered via intravenous infusion every four weeks in a healthcare setting. This regular administration requires patient commitment and monitoring to ensure safety and efficacy. Extended interval dosing may be an option for some, potentially reducing certain risks while maintaining effectiveness.
Risks and Monitoring
A significant risk associated with natalizumab is PML, a rare brain infection. Patients must be regularly screened for JC virus antibodies, which can indicate increased risk of PML. Other side effects can include liver issues and various infections, necessitating ongoing surveillance and management.
Frequently Asked Questions
It is given by IV infusion every four weeks.
PML is a rare brain infection linked to natalizumab treatment.
Yes, extended intervals may reduce risks.
Side effects include infections and liver issues.
Wrapping Up
Natalizumab offers significant benefits for MS but requires careful monitoring for potential risks.
References
- Tyruko (natalizumab-sztn) prescribing information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761322s000lbl.pdf
- Zhovtis Ryerson L, Frohman TC, Foley J, et al. Extended interval dosing of natalizumab in multiple sclerosis. J Neurol Neurosurg Psychiatry 2016; 87:885.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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