How Is Cushing Disease Treated?
Published: Jul 08, 2024
Effective treatment of Cushing Disease, a type of Cushing Syndrome, can significantly improve quality of life. Here's how medical therapy plays a role.
Contents
Surgical Interventions
For Cushing Disease, transsphenoidal surgery is often the best option. This procedure involves removing the pituitary tumor causing excess hormone production. When done by skilled surgeons, the success rate is around 70% to 80%, but there's a risk of recurrence.
Medication Options
When surgery isn't viable or successful, medications can help. Drugs that inhibit adrenal enzymes or target the pituitary hormone production can effectively control cortisol levels. Options like cabergoline and pasireotide have shown success in normalizing cortisol in many cases.
Role of Radiation Therapy
Radiation therapy is another treatment avenue, particularly when surgery is not an option. This method uses high-energy rays to target and reduce tumor size, effectively managing hormone levels with a success rate of up to 85% in adults.
Frequently Asked Questions
It's a form of Cushing Syndrome caused by a pituitary tumor.
Surgery is successful in 70% to 80% of cases, with some risk of recurrence.
Drugs like cabergoline and pasireotide are common.
Yes, it can be effective, especially when surgery isn't an option.
Key Takeaways
Choosing the right treatment for Cushing Disease depends on individual circumstances and medical advice.
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References
Fleseriu M, Biller BM, Findling JW, et al. Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome. J Clin Endocrinol Metab 2012; 97:2039.
Fleseriu M, Auchus R, Bancos I, et al. Consensus on diagnosis and management of Cushing's disease: a guideline update. Lancet Diabetes Endocrinol 2021; 9:847.
Always discuss health information with your healthcare provider.