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How is Acquired von Willebrand Syndrome Diagnosed?
Published: Aug 16, 2024
Diagnosing acquired von Willebrand syndrome (AVWS) involves a series of tests and evaluations to confirm the presence of the disorder. Let's take a closer look at the diagnostic process.
Initial Evaluation
The diagnosis of AVWS starts with a detailed medical history and physical examination. Doctors look for signs of bleeding and any underlying conditions that might trigger AVWS. A thorough review of the patient's medication list is also crucial, as some drugs can affect VWF levels.
Laboratory Testing
Key laboratory tests include measuring the levels of von Willebrand factor antigen, VWF activity, and factor VIII activity. These tests help determine if VWF levels are lower than normal and if the VWF is functioning properly. Additional tests may be needed to differentiate AVWS from inherited von Willebrand disease.
Advanced Diagnostics
In some cases, further testing like VWF multimer analysis or mixing studies may be conducted. These tests can provide more information about the structure and function of VWF and help identify the presence of autoantibodies. These advanced diagnostics are particularly useful in complex cases.
Frequently Asked Questions
AVWS is diagnosed through medical history, physical exams, and laboratory tests.
Tests measure VWF antigen and activity to assess levels and function.
Advanced tests like multimer analysis may be needed for complex cases.
Key Takeaways
Proper diagnosis of AVWS requires a combination of clinical evaluation and laboratory testing.
References
- Federici AB, Budde U, Castaman G, et al. Current diagnostic and therapeutic approaches to patients with acquired von Willebrand syndrome: a 2013 update. Semin Thromb Hemost 2013; 39:191.
- Nichols WL, Hultin MB, James AH, et al. von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia 2008; 14:171.
This article has been reviewed for accuracy by one of the licensed medical doctors working for Doctronic. Always discuss health information with your healthcare provider.
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